Aerodynamic Particle Size Distribution (APSD)

The Aerodynamic Particle Size Distribution (ASPD), along with Delivered dose, is widely recognised as a Critical Quality Attribute in the in vitro characterisation of OINDPs.
The ASPD of an aerosol will determine where the particles in that cloud are going to deposit in the body, amongst other information. Typically particles should be in the range of 1 to 5 microns to be effective, any larger than 5 microns and they are likely to impact the oropharynx and be swallowed, any smaller than 1 micron and it is possible that the particles will remain entrained in the air system.

Aerodynamic Particle Size Distribution

Please select an inhaler type for further information about Aerodynamic Particle Size Distribution testing.

APSD for Metered Dose Inhalers (MDIs) & Breath-Actuated Inhalers (BAIs)

The Aerodynamic Particle Size Distribution of a MDI or BAI will determine where the particles in the aerosol cloud are likely to deposit following inhalation. If the particles are too large they will catch at the back of the throat. Too small, and they will be exhaled rather than deposited.

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APSD for Dry Powder Inhalers (DPIs)

The Aerodynamic Particle Size Distribution of a DPI will determine where the particles in the aerosol cloud are likely to deposit following inhalation. If the particles are too large they will catch at the back of the throat. Too small, and they will be exhaled rather than deposited.

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APSD for Nebulisers

Nebulisers convert liquids into a cloud of droplets suitable for respiration. Conventional nebulisers are widely used in both hospital and home. Their main advantage is that unlike other devices, they require little or no coordination on the part of the patient in order to use them.

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APSD for Aqueous Droplet Inhalers (ADIs)

The Aerodynamic Particle Size Distribution of an ADI will determine where the particles in the aerosol cloud are likely to deposit following inhalation. If the particles are too large they will catch at the back of the throat. Too small, and they will be exhaled rather than deposited.

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