Tablet Dissolution Testing

Meeting the latest specifications as laid down in the European, United States and associated Pharmacopoeias, the DISi Series are a range of reliable and cost-efficient dissolution tester systems designed with the highest standards of solid dosage testing performance in mind. Designed to minimise user training and reduce the burden of routine equipment maintenance, the DISi dissolution tester series from Copley simplifies the dissolution testing process, without compromising on data quality.

Please select a DISi Series tester for further product information

DIS 600i DIS 800i

Easy-clean Viton® membrane-sealed zero-evaporation lids included as standard

Intuitive touchscreen control with icon-based menu structure simplifies operation

Robust metal case with advanced corrosion protective coating

PT100 temperature probe monitors bath and vessel temperature with electronic calibration feature

Independent digital heater/circulator maintains a constant temperature and minimises vibration

Easily removable leak-proof water bath with convenient drain tap eases bath water emptying

All vessels are serial-numbered as standard

Convenient screw-in basket/paddles enable easy method change in seconds

 

Maximum fill line indicator

 

‘Easy-Centre’ centring system for precise vessel positioning

DIS 600i

With bench space a premium in many laboratories, the DIS 600i is one of the most compact dissolution testers available on the market today.

Ideal for use in both R&D and QC environments, the DISi 600i is equipped with precision ground shafts that will accept any of the baskets, paddles or rotating cylinders described in the Ph. Eur., USP and associated Pharmacopoeias.

Catalogue Number:

1336

Pharmacopoeial Compliance:

Ph. Eur. 2.9.3 and 2.9.4

USP <711> and <724>

Ph. Eur. and USP Test Methods Supported:

1, 2, 5, 6

Number of Stirred Vessels:

6

Heater Type:

Low vibration independent external digital heater/circulator

Unit Dimensions (w x d x h):

728 x 495 x 689 mm (unit)
260 x 330 x 150 mm (heater)

Please select a DISi Series tester for further product information

DIS 600i DIS 800i

Easy-clean Viton® membrane-sealed zero-evaporation lids included as standard

Intuitive touchscreen control with icon-based menu structure simplifies operation

Robust metal case with advanced corrosion protective coating

PT100 temperature probe monitors bath and vessel temperature with electronic calibration feature

Independent digital heater/circulator maintains a constant temperature and minimises vibration

‘Easy-Centre’ centring system for precise vessel positioning

Maximum fill line indicator

 

Convenient screw-in basket/paddles enable easy method change in seconds

 

All vessels are serial-numbered as standard

Easily removable leak-proof water bath with convenient drain tap eases bath water emptying

DIS 800i

Maximising visibility and access to the critical sampling area above the bath, the DIS 800i represents the very latest in tablet testing technology.

Ideal for use in both R&D and QC environments, the DISi 800i is equipped with precision ground shafts that will accept any of the baskets, paddles or rotating cylinders described in the Ph. Eur., USP and associated Pharmacopoeias.

Catalogue Number:

1338

Pharmacopoeial Compliance:

Ph. Eur. 2.9.3 and 2.9.4

USP <711> and <724>

Eur. Ph & USP Test Methods Supported:

1, 2, 5, 6

Number of Stirred Vessels:

8

Heater Type:

Low vibration independent external digital heater/circulator

Unit Dimensions (w x d x h):

728 x 495 x 689 mm (without heater) 260 x 330 x 150 mm (heater)

Key DISi Series Highlights

Ph. Eur. and USP compliant

Integrated, precision temperature control and measurement

Intuitive touchscreen control to simplify operation

Single-point electronic temperature calibration

Six and eight test station unit configurations available

Extensive data reporting output options: RS 232, USB A and USB B

Wide speed range to accommodate broad scope of methods

Option to automate and remotely control DISi Series systems

DISi Compliance & Maintenance

  • Certificate of compliance to Ph. Eur./USP provided as standard
  • Comprehensive IQ/OQ/PQ documentation packages and toolkits available
  • Passcode-protected single-point electronic temperature calibration
  • Latest temperature calibration information stored and available to export/print

DISi Series Accessories

Baskets, Paddles & Rotating Cylinders

All the DISi series are equipped with precision-ground shafts that will accept any of the baskets, paddles or rotating cylinders described in the Pharmacopoeias. Individual clutches enable each individual basket/paddle to be raised/lowered or engaged independently of the drive head making the series suitable for staggered starts, whilst also ensuring maximum user accessibility.

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Baskets, Paddles & Rotating Cylinders

Standard Vessels & Lids

Compliant with USP/Eur. Ph. specifications, all DISi Series vessels feature unique Easy-Centre systems ensuring perfect positioning every time. UV-resistant vessels are also available. Easy-clean Viton® membrane-sealed low evaporation lids are included as standard with each vessel.

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Standard Vessels & Lids

EMC Ultra-Precision Vessels

With dimensional tolerances a factor of 2 higher than those specified in the FDA Enhanced Calibration, the EMC Ultra Precision Dissolution Vessel brings even higher levels of accuracy to dissolution testing.

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EMC Ultra-Precision Vessels

Automatic Tablet Drop

Eliminate the need for time-lag correction factor calculations with the Automatic Tablet Drop system. Guaranteeing simultaneous tablet ejection at the start of the test run, synchronised sampling is simplified.

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Automatic Tablet Drop

Sampling Probes

We offer a range of dissolution sampling probe systems, designed for different user requirements, including manual sample processes, as well as automated sampling.

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Sampling Probes

Performance Verification Testing (PVT)

Formulated to produce reproducible results under standard dissolution test conditions, these standard drug references supplied by USP (Rockville, Maryland, USA) can be used to help verify the source of anomalies.

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Performance Verification Testing (PVT)

DISi Series Calibration Tools

  • Calibration of the DISi Series temperature probe is simple, through the use of an electronic calibration key and pin-protected calibration menu designed to guide users through the process without fuss. The latest temperature probe calibration information is stored and available to print/export when convenient to the user.
  • To calibrate all other aspects of the DISi Series, our complete range of calibration and qualification tools can be used to safeguard compliance with the appropriate pharmacopoieal and regulatory guidance.
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Special Applications

Transdermal Patch Testing

Copley offers equipment for three different methods for the determination of the rate of drug release from transdermal patches:

  • Paddle Over Disk
  • Watch Glass / Patch
  • Rotating Cylinder
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Transdermal Patch Testing

Intrinsic Dissolution

Based on the same principles as the Rotating Disk apparatus as described in USP Chapter <1087>, Copley offers punch and die kits, together with a hand operated press for intrinsic dissolution methods.

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Intrinsic Dissolution

Small Volumes

For dosage forms with small quantities, or extended release where much lower concentrations are required than that provided by the standard 1000 mL vessel, 100 mL and 200 mL conversion kits are available.

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Small Volumes

Special Baskets

For solid dosage forms that have a tendency to block the standard 40 mesh basket, a basket with a coarser mesh is available to retain the dosage form in the basket, whilst allowing media penetration without clogging.

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Special Baskets

Baskets for Suppository Dissolution

With the same basic basket specification as the USP standard, the special suppository basket provides the equivalent porosity to a basket of 10 mesh, allowing suppository dissolution testing to take place unimpeded.

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Baskets for Suppository Dissolution

Inhaled Dissolution

In the case of inhaled and nasal drug delivery products, once the drug is deposited to the target site, the absorption or lung uptake, and hence the therapeutic effectiveness of the drug, depends on the active dissolving in the small amounts of aqueous fluid and lung surfactant available.

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Inhaled Dissolution

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