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APSD of Nasal Products

Nasal drug products typically produce droplets larger than 10-20 microns, to ensure nasal deposition and minimise deposition within the lungs. However, a proportion of fine droplets in the <10 micron range may also be produced. Deposition of this respirable fraction beyond the nasal tract may be undesirable and must be quantified. Aerodynamic particle sizing with a cascade impactor is a US FDA requirement and is recommended in USP <601> to assess potential deposition beyond the nasal cavity.

Our nasal product testing solutions enable better, more informative testing in line with evolving market requirements.

Nasal Sprays

Nasal Aerosols

Nasal Powders

Nasal Sprays

Nasal Aerosols

Nasal Powders

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)

Like nasal sprays, nasal aerosols also typically produce droplets in the range 20-200 microns, which is outside the effective range of cascade impactors. However, most aerosols typically deliver a proportion (typically <5%) of fine droplets in the <10 micron range, which must be quantified.

Used together with a cascade impactor such as the Next Generation Impactor (NGI) and a high volume expansion chamber, such as the Glass Expansion Chamber, the Vertus® III/Vertus® III+ automated shake, fire and flow control systems can be used to meet the need for highly consistent nasal aerosol actuation as recommended by USP <601>.

Shot weight measurement

The Vertus® III+ model includes an integrated analytical balance for automated nasal aerosol shot weight measurement.

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)

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Nasal Aerosols: Semi-Automated APSD Measurement

The Vertus® III automated shake, fire and flow range is made up of integrated turn-key solutions for precise, controlled and reproducible nasal aerosol testing. Compatible with most nasal aerosols, the Vertus III or Vertus III+ offers analysts complete control over:

The speed, angle and duration of shaking, ahead of actuation
Firing force and the speed of application and release of that force
The time delay between the end of shaking and device actuation

How Does a Cascade Impactor Work?

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Manual Nasal Aerosol Sampling

In addition to the Vertus® automated shake, fire and flow systems, we offer a full suite of products to support manual testing, including flow meters, flow controllers and vacuum pumps.

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Related Applications

We also offer a range of equipment for additional nasal aerosol testing application support:

Related Applications

Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.