Fast Screening Andersen (FSA)
The Fast Screening Andersen (FSA) is an AIM version of the standard full-resolution Andersen Cascade Impactor (ACI) suitably modified to provide a reduced stack plus filter (F) suitable for either:
- Quality Control (FSA-QC) or
- Product Development (FSA-HRT)
Once validated and implemented, such impactors can help to speed up the process of screening formulations in the early development phases, prior to full-resolution studies being performed on the most promising candidates.
In the FSA-QC, Stages 0 (or -1, or 2A) and F are used in conjunction with a Stage X, having a cut-off diameter as close as possible to the Mass Median Aerodynamic Diameter (MMAD) of the aerosol, as determined during full-resolution cascade impactor testing.
In the FSA-HRT, stages with cut-off diameters are available at 5.0 and 1.0 microns for MDI applications at 28.3 L/min. Stages having more traditional cut-off points of 4.7 and 1.1 microns are also available for varying flow rates, primarily for DPI applications.
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