Introduction to Thickness Testing

The thickness of tablets is critical to their therapeutic effectiveness.

All tablets, where the active ingredient comprises a major part of the tablet are required to meet a weight variation test. It is assumed that providing the weight of the tablet is kept within defined limits that the amount of active drug available to the user will remain the same.

The weight of a compressed tablet is dependent on three factors:
density, diameter and thickness. In theory, the density of the powder blend and the diameter of the resultant tablet (which is dictated by the die wall) should remain unchanged.

It follows that by monitoring the thickness of the tablets at regular intervals, potential problems relating to tablet weight and hence content uniformity can be detected at an early stage.

The calipers and thickness testers featured in this section are simple, easy to use instruments designed for use by the press operator on the compression floor.

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