Semisolids Testing

Copley offers the HDT Series designed for the assessment of drug release from semisolid formulations. The range includes innovative dry-heat systems and the more traditional water-jacketed heating systems.

HDT 1

HDT 1

A compact water-jacketed testing system supporting a single vertical diffusion cell, ideal for entry-level semisolids testing.

Catalogue Number:

7276

Pharmacopoeial Compliance:

USP <1724>

Cell Capacity:

1 single vertical diffusion cell

Cell Types Supported:

B, C and Skin

Heating System:

Water bath

Sampling Technique Compatibility:

Endpoint, Discrete, Fully automatic

Unit Dimensions (w x d x h):

190 x 300 x 100 mm

Key HDT 1 Highlights

USP Compliant

Precision control over all test parameters

Novel cell clamps simplify cell preparation

Powerful magnetic stirrers ensure consistent mixing during testing

HDT unit footprint smaller than an A4 piece of paper

Related Accessories

Cells: Type ‘B’ and ‘C’

Copley’s Type ‘B’ and ‘C’ cells feature a unique clamping system to simplify cell preparation and sample collection procedures. Cells are supplied complete with individual cell tops for both ‘closed or occluded’ operation (as per USP Model ‘A’) and ‘open’ operation (as per USP Models ‘B’ and ‘C’ respectively, maximising the versatility of the HDT 1000 and HDT-1 systems.

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Cells: Type ‘B’ and ‘C’

Cells: Skin

To accommodate ‘full thickness’ membranes or skin, a new screw-type cell closure mechanism has been developed for the skin specific cell that ensures proper contact between the sample and the receptor medium. All components of the cell are made from FDA-approved inert materials and a side sampling arm facilitates easy filling, sample withdrawal and media replacement.

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Cells: Skin

Membranes

Copley offers a range of three synthetic membranes: PVDF, Supor Polyethersulfone and Strat-M.

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Membranes

Degassing

The Vacuum Deaeration Apparatus Model, VDA, from Copley is an easy-to-use and inexpensive unit designed to degas receptor medium prior to its use, ensuring that diffusion is unimpeded by the collection of gas beneath the membrane.

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Degassing

Immersion Cell

  • An alternative to the Vertical Diffusion or Franz Cell for testing semisolids, the Immersion Cell (USP Model A) is described with the conventional USP Apparatus 2 for Dissolution testing.
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