Realistic Throat and Nasal Models

The standard Ph.Eur./USP Induction Port is known to poorly represent aerosol transport through the upper respiratory tract. Using more realistic throat and nasal models enables a more representative assessment of drug delivery to the target site.

Alberta Idealised Throat AIT

For orally inhaled products (OIPs), the AIT provides analysts with data more representative of measured in vivo behaviour, by ensuring that the ISM corresponds with the portion of the aerosol that would likely enter the lungs. With a standardised, highly reproducible, humanlike geometry, the AIT offers robust performance independent of flow rate and is designed to make drug recovery quick and simple.

  • Idealised geometry represents a range of patient groups

  • Smooth, uniform internal geometry to allow for coating and to ensure inter-throat uniformity

  • Quick-release clips make internal coating and drug recovery quick and simple

  • Chemically compatible with a wide range of drug recovery solvents

  • Adult and Child (6-14 years) versions available

Regions represented by the AIT

The drug mass sized by the cascade impactor (impactor sized mass) should ideally be representative of the dose that would actually enter the lungs.

The AIT has a four-region resolution:

  • the oral cavity
  • the pharynx
  • the epiglottis
  • the larynx

Knowledge of the portion of the dose captured in the throat is essential to understand the dosage delivery characteristics of a given orally inhaled product (OIP). In many cases, the portion of the dose collected in the throat represents a significant proportion of the delivered dose.

The throat models we offer were developed from extensive research into typical patient populations including information provided by CT and MRI scans, direct observation of living subjects and data in the archival literature. More information and references are available on request.

System for Improved In Vitro-In Vivo Correlations (IVIVCs) of Inhaled Drug Products

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