Breathing Simulators

From the generation of simple sinusoidal patterns as stated by the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of versatile Breathing Simulators can be used for a variety of testing applications and patient physiologies.

Breathing Simulator BRS 200i

BRS 200i Breathing Simulator

The BRS 200i is a breathing simulator with up to 900 mL volume suitable for the testing of Nebulisers and MDIs with Spacers and Valve Holding Chambers (VHCs). Designed specifically to generate all of the breathing profiles used to measure the drug delivery rate and tidal drug delivered of nebulisers according to Ph. Eur. 2.9.44 and USP <1601> and <1602>, the BRS 200i is also suitable for generating other wave forms used in improved IVIVC studies.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Improved accuracy for infant and neonate profile volume requirements

  • Extensive data output options

BRS 200i Features
Volume:
0 to 900 mL
Frequency:
6 - 60 bpm
I:E Ratio:
Variable
Waveforms:
Sinusoidal, Square, Triangular, User-defined (flow vs time)
Profile:
Inhalation and/or Exhalation
Start:
On inhalation or exhalation stroke / User-defined profiles (flow vs time)
User Interface:
Touchscreen
Uses:
Testing Nebulisers (Ph. Eur. 2.9.44) and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)
BRS 200i, NGI Cooler, NGI, Vacuum Pump, TPK-R and Nebuliser

NGI Cooler Stand

The NGI Cooler Stand supports the interfacing of the NGI Cooler with the BRS 200i, whilst saving precious benchtop space.

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Real-Time-Breath-Verification-Chamber

Real-Time Breath Verification Chamber

Enables measurement and recording of the breathing profile generated through the inhaler during the actual test itself, using the Flow Certifier available in the Qualification Kit. Support Arm (Cat. No. 9113) required. For use with the USP Induction Port only.

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