Breathing Simulators

Representative breathing patterns should be employed during inhaler testing that characterise the age and condition of the patients to be treated (paediatric to geriatric, mild to severe impairment of the lungs).
The Copley range of Breathing Simulators are designed to generate an inhalation and/or exhalation profile that mimics that of a human subject and have become routinely used in orally inhaled product testing to replace existing constant flow conditions with breathing profiles more representative of conditions in vivo.

BRS 2100 - Breathing Simulator

The BRS 2100 is a second generation, advanced embedded computer-controlled breathing simulator with up to 900 mL volume suitable for the testing of Nebulisers and MDIs with Spacers and Valve Holding Chambers (VHCs). Designed specifically to generate all of the breathing profiles used in measuring the drug delivery rate and tidal drug delivered of nebulisers according to Ph. Eur. 2.9.44 and USP <1601> and <1602>, the BRS 2100 is also suitable for generating other wave forms used in improved IVIVC studies.

BRS 2100 Features
Volume (computer controlled):
0 to 900 mL
Frequency:
0+ (upper defined by acceleration limit)
I:E Ratio:
Variable
Waveforms:
Sinusoidal, Square, Triangular, User defined (flow vs time)
Profile:
Inhalation and/or Exhalation
Start:
On inhalation or exhalation stroke User defined profiles (flow vs time)
User Interface:
Embedded computer (Windows 10)
Uses:
Testing Nebulisers (Ph. Eur. 2.9.44 and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

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