{"id":52369,"date":"2023-12-13T09:14:08","date_gmt":"2023-12-13T09:14:08","guid":{"rendered":"https:\/\/copley1.wpenginepowered.com\/blogs\/2023%e5%b9%b4%e8%82%ba%e9%83%a8%e8%8d%af%e7%89%a9%e9%80%92%e9%80%81%e4%bc%9a%e8%ae%ae-ddl-23%ef%bc%9a%e4%b8%ba%e7%b2%be%e5%bd%a9%e7%9a%84%e4%b8%80%e5%b9%b4%e7%94%bb%e4%b8%8a%e5%ae%8c%e7%be%8e\/"},"modified":"2024-02-16T10:05:40","modified_gmt":"2024-02-16T10:05:40","slug":"2023%e5%b9%b4%e8%82%ba%e9%83%a8%e8%8d%af%e7%89%a9%e9%80%92%e9%80%81%e4%bc%9a%e8%ae%ae-ddl-23%ef%bc%9a%e4%b8%ba%e7%b2%be%e5%bd%a9%e7%9a%84%e4%b8%80%e5%b9%b4%e7%94%bb%e4%b8%8a%e5%ae%8c%e7%be%8e","status":"publish","type":"blog_type","link":"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/2023%e5%b9%b4%e8%82%ba%e9%83%a8%e8%8d%af%e7%89%a9%e9%80%92%e9%80%81%e4%bc%9a%e8%ae%ae-ddl-23%ef%bc%9a%e4%b8%ba%e7%b2%be%e5%bd%a9%e7%9a%84%e4%b8%80%e5%b9%b4%e7%94%bb%e4%b8%8a%e5%ae%8c%e7%be%8e\/","title":{"rendered":"2023\u5e74\u80ba\u90e8\u836f\u7269\u9012\u9001\u4f1a\u8bae (DDL 23)\uff1a\u4e3a\u7cbe\u5f69\u7684\u4e00\u5e74\u753b\u4e0a\u5b8c\u7f8e\u53e5\u53f7"},"content":{"rendered":"
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\u5438\u5165\u836f\u7269\u9012\u9001\u4f1a\u8bae\u65e5\u7a0b\u4e2d\u7684\u5173\u952e\u6d3b\u52a8\u4eae\u70b9<\/em><\/h2>\n

\u6574\u4e2a\u7231\u4e01\u5821\u6c89\u6d78\u5728\u5723\u8bde\u5b63\u6c1b\u56f4\u4e2d\uff0c\u6765\u81ea\u5168\u7403\u5404\u5730\u7684\u6f14\u8bb2\u5609\u5bbe\u9f50\u805a\u4e00\u5802\uff0c\u63d0\u4f9b\u4e86\u5343\u8f7d\u96be\u9022\u7684\u4ea4\u6d41\u673a\u4f1a\uff1a\u8fd9\u5c31\u662f\u80ba\u90e8\u836f\u7269\u9012\u9001\u4f1a\u8bae\u7684\u72ec\u5177\u9b45\u529b\u4e4b\u5904\u3002\u4f5c\u4e3a\u7ecf\u53e3\u5438\u5165\u5236\u5242\u548c\u9f3b\u7528\u836f\u7269\u4ea7\u54c1 (OINDP) \u6d3b\u52a8\u65e5\u7a0b\u4e2d\u7684\u4e00\u573a\u91cd\u8981\u76db\u4f1a\uff0cDDL 23\u771f\u6b63\u91cd\u73b0\u4e86\u5f80\u65e5\u7684\u8f89\u714c\u3002Copley\u56e2\u961f\u5ea6\u8fc7\u4e86\u7cbe\u5f69\u7684\u4e09\u5929\uff0c\u539f\u56e0\u5982\u4e0b\uff1a<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n\n\n

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\u6211\u4eec\u6df1\u53d7\u9f13\u821e\uff1a<\/strong><\/h5>\n

\u9047\u89c1\u4e86UPC Cambridge Ltd\u7684\u533b\u5b66\u987e\u95eeCarrie Vaillencourt\uff0c\u5176\u76ee\u524d\u6b63\u5728\u8bad\u7ec3\u5907\u62182024\u5e74\u4f26\u6566\u9a6c\u62c9\u677e\u3002\u4e00\u5e74\u591a\u524d\uff0cCarrie\u56e0\u4e2d\u98ce\u800c\u5b8c\u5168\u762b\u75ea\uff0c\u4e00\u5ea6\u8ba4\u4e3a\u81ea\u5df1\u6c38\u8fdc\u65e0\u6cd5\u5eb7\u590d\u3002\u5979\u968f\u540e\u4e0b\u5b9a\u51b3\u5fc3\u6297\u4e89\u75c5\u9b54\uff0c\u5728\u4e2d\u98ce\u540e\u7684\u51e0\u5468\u5185\u5c31\u8bd5\u7740\u201c\u8d70\u201d\u4e86\u4e00\u5c0f\u6bb5\u8ddd\u79bb\uff0c\u867d\u7136\u82b1\u4e866\u5206\u949f\u65f6\u95f4\u624d\u8d70\u4e86\u51e0\u7c73\u3002\u4e00\u5e74\u540e\uff0c\u5979\u7684\u8fdb\u6b65\u975e\u5e38\u60ca\u4eba\u3002Carrie\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5728DDL\u89c1\u5230\u60a8\uff0c\u660e\u5e74\u6211\u4eec\u4f1a\u7ee7\u7eed\u652f\u6301\u60a8\u3002<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n\n\n

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\n \"DDL\n <\/div>\n \n \n Daniela Traini\u53d1\u8868DDL\u5e74\u5ea6\u6f14\u8bb2 <\/span>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n\n\n\n\n
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\u6211\u4eec\u52a8\u529b\u5341\u8db3\uff1a<\/strong><\/h5>\n

\u91cd\u70b9\u5173\u6ce8\u4f53\u5916<\/em>\u6d4b\u8bd5\u7684\u65b0\u6311\u6218\uff0c\u7279\u522b\u662f\u5728\u51cf\u5c11\u5bf9\u5176\u4ed6\u590d\u6742\u6d4b\u8bd5\u5f62\u5f0f\u4f9d\u8d56\u6027\u7684\u80cc\u666f\u4e0b\u3002\u4f8b\u5982\uff0cTraini\u6559\u6388\u7684\u4e3b\u9898\u6f14\u8bb2\u201cOf mice and men: Correlation and clinical relevance of animal models and non-clinical tests\u201d(\u4eba\u9f20\u4e4b\u95f4\uff1a\u52a8\u7269\u6a21\u578b\u4e0e\u975e\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76f8\u4e92\u5173\u7cfb\u548c\u4e34\u5e8a\u76f8\u5173\u6027)\u63a2\u8ba8\u4e86\u5f97\u76ca\u4e8e2022\u5e74\u300aFDA\u73b0\u4ee3\u5316\u6cd5\u6848\u300b\uff0c\u5982\u4f55\u53ea\u901a\u8fc7\u975e\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u5c31\u80fd\u8fdb\u884c\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u662f\u4e00\u573a\u53d1\u4eba\u6df1\u7701\u7684\u4f1a\u8bae\uff0c\u5f3a\u8c03\u4e86\u4f7f\u7528\u7ec6\u80de\u548c\u5b9e\u9a8c\u5ba4\u57f9\u517b\u7684\u7ec4\u7ec7\u3001\u5668\u5b98\u82af\u7247\u548c\u8ba1\u7b97\u673a\u6a21\u578b\u7b49\u5de5\u5177\u6765\u51cf\u5c11\u5bf9\u52a8\u7269\u6a21\u578b\u7684\u4f9d\u8d56\u6027\uff0c\u6211\u4eec\u4e00\u81f4\u8ba4\u4e3a\u8fd9\u5c06\u662f\u4e00\u9879\u91cd\u5927\u8fdb\u6b65\u3002<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n\n\n

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\n \"Copley\n <\/div>\n \n \n Vertus\u00ae III+\u548cDecaVertus\u00ae III\u7ed9\u4eba\u7559\u4e0b\u4e86\u826f\u597d\u7684\u7b2c\u4e00\u5370\u8c61\u3002 <\/span>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n\n\n\n\n
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\u6211\u4eec\u611f\u5230\u559c\u60a6\uff1a<\/strong><\/h5>\n

\u4f5c\u4e3a\u5bf9Vertus\u00ae III+\u548cDecaVertus\u00ae III<\/a>\u7684\u56de\u5e94\uff0c\u6211\u4eec\u7684\u65b0\u578b\u5168\u81ea\u52a8\u632f\u6447\u3001\u55b7\u5c04\u3001\u6d41\u91cf\u63a7\u5236\u548c\u55b7\u5c04\u91cf\u6d4b\u91cf\u5e73\u53f0 (\u7528\u4e8e\u9f3b\u7528\u55b7\u96fe\u5242\u548c\u5b9a\u91cf\u5438\u5165\u5242 (MDI) \u6d4b\u8bd5) \u5728DDL\u4e0a\u9996\u6b21\u4eae\u76f8\u3002\u73b0\u6709\u5ba2\u6237\u5bf9\u5176\u65b0\u529f\u80fd\u5370\u8c61\u6df1\u523b\uff0c\u800c\u90a3\u4e9b\u521d\u6b21\u63a5\u89e6Vertus\u7406\u5ff5\u7684\u5ba2\u6237\u5219\u88ab\u5176\u6f5c\u529b\u6240\u6298\u670d\u3002\u4e00\u4f4d\u6765\u81ea\u9886\u5148\u5438\u5165\u5236\u5242\u5408\u540c\u5f00\u53d1\u548c\u5236\u9020\u7ec4\u7ec7\u7684\u53c2\u89c2\u8005\u5728\u7b2c\u4e00\u5929\u5c31\u88ab\u6df1\u6df1\u6253\u52a8\uff0c\u7b2c\u4e8c\u5929\u4ed6\u4eec\u5c31\u5e26\u7740\u53e6\u4e00\u5bb6\u4ea7\u54c1\u5f00\u53d1\u516c\u53f8\u7684\u8054\u7cfb\u4eba\u56de\u6765\u89c2\u770b\u66f4\u6df1\u5165\u7684\u6f14\u793a\u3002\u6211\u4eec\u518d\u4e5f\u627e\u4e0d\u5230\u6bd4\u8fd9\u66f4\u597d\u7684\u63a8\u8350\u4e86\u3002<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n\n\n

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\n \"Copley\n <\/div>\n \n \n Ben\u5173\u4e8e\u5242\u91cf\u548c\u963b\u529b\u8865\u507f\u5668 (VRC) \u7684\u6f14\u8bb2\u5c06\u5f15\u53d1DPI\u4e13\u4e1a\u4eba\u5458\u7684\u5174\u8da3\u3002 <\/span>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n\n\n\n\n
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\u6b64\u5916\uff0cBen Bradley\u7684\u6d77\u62a5\u8ba8\u8bba\u4f1a\u4e5f\u53d7\u5230\u4e86\u70ed\u70c8\u6b22\u8fce\u3002\u201c\u5c06DUSA\u548c\u649e\u51fb\u5668\u4e0a\u5347\u65f6\u95f4\u66f2\u7ebf\u4e0e\u5242\u91cf\u548c\u963b\u529b\u8865\u507f\u5668\u76f8\u5339\u914d\u201d\u662f\u4efb\u4f55\u5e0c\u671b\u6539\u8fdb\u5438\u5165\u5236\u5242\u6d4b\u8bd5\u5b9e\u8df5\u7684\u5de5\u4f5c\u4eba\u5458\u7684\u7edd\u4f73\u9009\u62e9<\/a>\uff0c\u5c24\u5176\u662f\u5e72\u7c89\u5438\u5165\u5242 (DPI)\u3002<\/p>\n

\u6211\u4eec\u4e07\u4e8b\u4ff1\u5907\uff1a<\/strong><\/h5>\n

\u7d27\u8ddf\u6240\u6709\u4e3b\u5bfc\u884c\u4e1a\u4e3b\u9898\uff0c\u5305\u62ec\u5229\u7528\u5168\u7403\u53d8\u6696\u6f5c\u80fd\u503c\u8f83\u4f4e (low GWP) \u7684\u63a8\u8fdb\u5242\u91cd\u65b0\u8bbe\u8ba1MDI\u914d\u65b9\u3001\u5438\u5165\u751f\u7269\u5236\u54c1\u4ee5\u53ca\u5bf9\u9f3b\u8154\u836f\u7269\u9012\u9001\u4ea7\u54c1\u65e5\u76ca\u589e\u52a0\u7684\u5173\u6ce8\u3002\u5728\u8fd9\u4e9b\u9886\u57df\u6709\u8bb8\u591a\u6709\u4ef7\u503c\u7684\u6f14\u8bb2\u548c\u6587\u7ae0\uff0c\u6d89\u53ca\u60a3\u8005\u9075\u4ece\u6027\u8fd9\u4e2a\u6301\u7eed\u6027\u95ee\u9898\uff0c\u8fd9\u5bf9\u60a3\u8005\u6cbb\u7597\u6548\u679c\u548c\u533b\u7597\u4fdd\u5065\u9884\u7b97\u4ecd\u4fdd\u6301\u7740\u91cd\u5927\u5f71\u54cd\u3002\u6570\u5b57\u89e3\u51b3\u65b9\u6848\u548c\u4eba\u5de5\u667a\u80fd\u6709\u671b\u6700\u7ec8\u89e3\u51b3\u8fd9\u4e00\u68d8\u624b\u95ee\u9898\uff1f<\/p>\n

\u6211\u4eec\u4e50\u4eab\u5176\u4e2d\uff1a<\/strong><\/h5>\n

\u6b64\u6b21\u91cd\u56de\u7231\u4e01\u5821\uff0c\u6211\u4eec\u89c1\u5230\u4e86\u591a\u5e74\u672a\u89c1\u7684\u8001\u9762\u5b54\uff0c\u8fd8\u53c2\u52a0\u4e86\u8fd9\u573a\u9886\u5148\u7684\u76db\u4f1a\u3002\u5728\u8fd9\u91cc\uff0c\u6709\u6fc0\u52a8\u4eba\u5fc3\u7684\u63a2\u8ba8\uff0c\u6709\u4e0d\u5c11\u7cbe\u5f69\u7684\u5ba3\u4f20\u6d77\u62a5\uff0c\u6709\u7e41\u5fd9\u7684\u5c55\u89c8\u4f1a\uff0c\u6709\u5f88\u68d2\u7684\u793e\u4ea4\u6d3b\u52a8\uff0c\u5f53\u7136\u8fd8\u6709\u98ce\u7b1b\u6f14\u594f\u3002\u6709\u4ec0\u4e48\u7406\u7531\u4e0d\u559c\u6b22\u5b83\u5462\uff1f<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n\n\n

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\n \"Castle\n <\/div>\n \n \n \u611f\u8c22\u6240\u6709\u7ec4\u7ec7\u8005\u3001\u6f14\u8bb2\u8005\u548c\u53c2\u4f1a\u8005\u4e3a\u672c\u5c4aDDL\u7684\u6210\u529f\u4e3e\u529e\u6240\u4f5c\u51fa\u7684\u8d21\u732e\u3002(Copley\u56e2\u961f\uff0c\u4ece\u5de6\u81f3\u53f3\uff1aMatt Fenn\u3001Clair Brooks\u3001Jamie Clayton\u3001Wynter Yeomans\u548cMark Copley) <\/span>\n <\/div>\n <\/div>\n <\/div>\n <\/section>\n\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":50426,"menu_order":50,"template":"","meta":{"footnotes":""},"categories":[200],"tags":[],"class_list":["post-52369","blog_type","type-blog_type","status-publish","has-post-thumbnail","hentry","category-200"],"acf":[],"yoast_head":"\n2023\u5e74\u80ba\u90e8\u836f\u7269\u9012\u9001\u4f1a\u8bae (DDL 23)\uff1a\u4e3a\u7cbe\u5f69\u7684\u4e00\u5e74\u753b\u4e0a\u5b8c\u7f8e\u53e5\u53f7 - Copley Scientific<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/2023\u5e74\u80ba\u90e8\u836f\u7269\u9012\u9001\u4f1a\u8bae-ddl-23\uff1a\u4e3a\u7cbe\u5f69\u7684\u4e00\u5e74\u753b\u4e0a\u5b8c\u7f8e\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"2023\u5e74\u80ba\u90e8\u836f\u7269\u9012\u9001\u4f1a\u8bae (DDL 23)\uff1a\u4e3a\u7cbe\u5f69\u7684\u4e00\u5e74\u753b\u4e0a\u5b8c\u7f8e\u53e5\u53f7 - 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