{"id":60757,"date":"2025-07-16T11:33:33","date_gmt":"2025-07-16T10:33:33","guid":{"rendered":"https:\/\/copley1.wpenginepowered.com\/?post_type=blog_type&p=60757"},"modified":"2026-01-29T16:21:18","modified_gmt":"2026-01-29T16:21:18","slug":"%e6%8f%90%e9%ab%98oindp%e6%b5%8b%e8%af%95%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%b8%e5%85%b3%e6%80%a7%ef%bc%9a%e8%a7%a3%e6%9e%90%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bb%a5%e5%8f%8a-3","status":"publish","type":"blog_type","link":"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/%e6%8f%90%e9%ab%98oindp%e6%b5%8b%e8%af%95%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%b8%e5%85%b3%e6%80%a7%ef%bc%9a%e8%a7%a3%e6%9e%90%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bb%a5%e5%8f%8a-3\/","title":{"rendered":"\u63d0\u9ad8OINDP\u6d4b\u8bd5\u7684\u4e34\u5e8a\u76f8\u5173\u6027 – \u7b2c\u4e8c\u7bc7"},"content":{"rendered":"
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\u6b22\u8fce\u56de\u5230\u6211\u4eec\u7684\u535a\u6587\u7cfb\u5217 (\u5206\u4e3a\u4e09\u7bc7)\uff0c\u672c\u671f\u5c06\u4ecb\u7ecd\u5728\u7ecf\u53e3\u5438\u5165\u5236\u5242\u53ca\u9f3b\u7528\u5236\u5242 (OINDP) \u6d4b\u8bd5\u4e2d\u63d0\u9ad8\u4f53\u5916\u4f53\u5185\u76f8\u5173\u6027 (IVIVC) \u7684\u91cd\u8981\u6027\u3002<\/em><\/h2>\n

\u5728\u672c\u7cfb\u5217\u7684\u7b2c\u4e00\u7bc7\u4e2d<\/a>\uff0c\u6211\u4eec\u63a2\u8ba8\u4e86\u4e34\u5e8a\u76f8\u5173\u6027\u4e3a\u4f55\u91cd\u8981\uff0c\u4ee5\u53ca\u5982\u4f55\u4f7f\u7528\u54bd\u5589\u548c\u9f3b\u8154\u6a21\u578b\u6765\u5b9e\u73b0\u8fd9\u4e00\u76ee\u6807\u3002\u5728\u7b2c\u4e8c\u7bc7\u4e2d\uff0c\u6211\u4eec\u5c06\u91cd\u70b9\u5173\u6ce8\u547c\u5438\u66f2\u7ebf\uff0c\u8fd9\u662fOINDP\u6027\u80fd\u6d4b\u8bd5\u4e2d\u81f3\u5173\u91cd\u8981\u5374\u5e38\u88ab\u8fc7\u5ea6\u7b80\u5316\u7684\u56e0\u7d20\u3002<\/p>\n

\u4e3a\u4ec0\u4e48\u547c\u5438\u66f2\u7ebf\u5982\u6b64\u91cd\u8981<\/strong><\/h5>\n

\u5173\u4e8e\u60a3\u8005\u5982\u4f55\u4f7f\u7528OINDP\u7684\u547c\u5438\u5efa\u8bae\uff0c\u4f1a\u56e0\u4ea7\u54c1\u7c7b\u578b\u800c\u6709\u6240\u5dee\u5f02\u3002\u5bf9\u4e8e\u5e72\u7c89\u5438\u5165\u5242 (DPI)\uff0c\u4e00\u822c\u64cd\u4f5c\u6307\u793a\u662f\u5feb\u901f\u6df1\u5438\u4e00\u53e3\u6c14\uff1b\u800c\u5bf9\u4e8e\u5b9a\u91cf\u5438\u5165\u5242 (MDI)\uff0c\u5219\u5efa\u8bae\u7f13\u6162\u6df1\u5438\u4e00\u53e3\u6c14\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u9f3b\u8154\u55b7\u96fe\u5242\u4f7f\u7528\u8005\u53ef\u80fd\u4f1a\u88ab\u544a\u77e5\u907f\u514d\u6df1\u5438\u6c14\uff0c\u800c\u4f7f\u7528\u96fe\u5316\u5668\u65f6\uff0c\u60a3\u8005\u4ec5\u9700\u6b63\u5e38\u547c\u5438\u5373\u53ef\u3002<\/p>\n

\u4e5f\u5c31\u662f\u8bf4\uff0c\u6bcf\u79cdOINDP\u6709\u4e0d\u540c\u7684\u63a8\u8350\u5438\u5165\u6280\u5de7\uff0c\u4f46\u60a3\u8005\u5bf9\u8fd9\u4e9b\u64cd\u4f5c\u65b9\u6cd5\u7684\u638c\u63e1\u7a0b\u5ea6\u53ef\u80fd\u53c2\u5dee\u4e0d\u9f50\u3002\u5373\u4f7f\u5728\u4f7f\u7528\u76f8\u540c\u7c7b\u578bOINDP\u7684\u60a3\u8005\u4e2d\uff0c\u5438\u5165\u6280\u5de7\u4e5f\u53ef\u80fd\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002<\/p>\n

\u5728\u6d4b\u8bd5\u8fc7\u7a0b\u4e2d\u6a21\u62df\u771f\u5b9e\u7684\u547c\u5438\u66f2\u7ebf\uff0c\u6709\u52a9\u4e8e\u6211\u4eec\u7406\u89e3\u6b64\u7c7b\u5dee\u5f02\u5982\u4f55\u5f71\u54cd\u836f\u7269\u9012\u9001\uff0c\u5e76\u8bc4\u4f30\u60a3\u8005\u751f\u7406\u673a\u80fd\u4e0e\u64cd\u4f5c\u4e60\u60ef\u5dee\u5f02\u4ea7\u751f\u7684\u5f71\u54cd\u3002\u8fd9\u5bf9\u90a3\u4e9b\u81f4\u529b\u4e8e\u6539\u8fdbIVIVC\u7684\u4eba\u58eb\u800c\u8a00\u6781\u6709\u4ef7\u503c\u3002<\/p>\n

\u836f\u5178\u65b9\u6cd5\u6709\u54ea\u4e9b\u8981\u6c42\uff1f<\/strong><\/h5>\n

\u5927\u591a\u6570\u836f\u5178\u65b9\u6cd5\u5728\u6d4b\u8bd5\u8fc7\u7a0b\u4e2d\u91c7\u7528\u7b80\u5355\u7684\u65b9\u6ce2\u6c14\u6d41\u66f2\u7ebf\uff0c\u5373\u5728\u6d4b\u8bd5\u8fc7\u7a0b\u4e2d\u91c7\u7528\u5f00\u542f\/\u5173\u95ed\u673a\u5236\uff0c\u4fdd\u6301\u6c14\u6d41\u901f\u7387\u6052\u5b9a\u4e0d\u53d8\u3002\u4f46\u5b58\u5728\u4e24\u4e2a\u5173\u952e\u7684\u4f8b\u5916\u60c5\u51b5\uff1a<\/p>\n

\u96fe\u5316\u5438\u5165\u5242\u9012\u9001\u5242\u91cf\u5747\u4e00\u6027 (DDU) \u6d4b\u8bd5<\/strong><\/h6>\n
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<\/p><\/div><\/div><\/td>

Adult<\/strong><\/p><\/div><\/div><\/td>

Neonatal<\/strong><\/p><\/div><\/div><\/td>

Infant<\/strong><\/p><\/div><\/div><\/td>

Child<\/strong><\/p><\/div><\/div><\/td><\/tr>

Total Volume<\/strong><\/p><\/div><\/div><\/td>

500 ml<\/p><\/div><\/div><\/td>

25 ml<\/p><\/div><\/div><\/td>

50 ml<\/p><\/div><\/div><\/td>

155 ml<\/p><\/div><\/div><\/td><\/tr>

Frequency<\/strong><\/p><\/div><\/div><\/td>

15 cycles\/min<\/p><\/div><\/div><\/td>

40 cycles\/min<\/p><\/div><\/div><\/td>

30 cycles\/min<\/p><\/div><\/div><\/td>

25 cycles\/min<\/p><\/div><\/div><\/td><\/tr>

Waveform<\/strong><\/p><\/div><\/div><\/td>

Sinusoidal<\/p><\/div><\/div><\/td>

Sinusoidal<\/p><\/div><\/div><\/td>

Sinusoidal<\/p><\/div><\/div><\/td>

Sinusoidal<\/p><\/div><\/div><\/td><\/tr>

I\/E Ratio<\/strong><\/p><\/div><\/div><\/td>

1:1<\/p><\/div><\/div><\/td>

1:3<\/p><\/div><\/div><\/td>

1:3<\/p><\/div><\/div><\/td>

1:2<\/p><\/div><\/div><\/td><\/tr><\/tbody><\/table>\n<\/div>\n\n

\u4e0a\u8868\u5c55\u793a\u4e86\u96fe\u5316\u5438\u5165\u5242DDU\u6d4b\u8bd5\u7684\u547c\u5438\u66f2\u7ebf\uff0c\u9002\u7528\u4e8e\u4e0d\u540c\u60a3\u8005\u7fa4\u4f53\uff0c\u5177\u4f53\u8981\u6c42\u53c2\u89c1\u300a\u7f8e\u56fd\u836f\u5178\u300b<1601>\u548c\u300a\u6b27\u6d32\u836f\u5178\u300b2.9.44\u3002\u5728\u6307\u5b9a\u65f6\u95f4\u6bb5\u5185 (\u901a\u5e38\u4e3a60\u79d2)\uff0c\u540c\u65f6\u6d4b\u91cf\u6709\u6548\u836f\u7269\u8f93\u9001\u901f\u7387\u4e0e\u836f\u7269\u9012\u9001\u603b\u91cf\u3002<\/p>\n

\u914d\u5907\u9644\u52a0\u88c5\u7f6e\u7684MDI\u7684DDU\u6d4b\u8bd5<\/strong><\/h6>\n

\u7f8e\u56fd\u836f\u5178<1602>\u89c4\u5b9a\u4e86\u914d\u5907\u9644\u52a0\u88c5\u7f6e (\u5982\u50a8\u96fe\u7f50\u548c\u5355\u5411\u9600\u50a8\u96fe\u7f50) \u7684MDI\u7684\u6d4b\u8bd5\u89c4\u8303 (\u53c2\u89c1\u4e0b\u8868)\u3002\u6b64\u65b9\u6cd5\u8fd8\u4f1a\u6a21\u62df\u6b63\u786e\u4f7f\u7528\u548c\u4e0d\u5f53\u4f7f\u7528\uff0c\u4ee5\u8bc4\u4f30\u60a3\u8005\u5728\u88c5\u7f6e\u542f\u7528\u65f6\u5438\u6c14\u6216\u547c\u6c14\u4ea7\u751f\u7684\u5f71\u54cd\u3002<\/p>\n

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Parameter<\/strong><\/p><\/div><\/div><\/td>

Neonate<\/strong><\/p><\/div><\/div><\/td>

Infant<\/strong><\/p><\/div><\/div><\/td>

Child<\/strong><\/p><\/div><\/div><\/td>

Adult 1<\/strong><\/p><\/div><\/div><\/td>

Adult 2<\/strong><\/p><\/div><\/div><\/td><\/tr>

Tidal volume (ml)<\/strong><\/p><\/div><\/div><\/td>

25<\/p><\/div><\/div><\/td>

50<\/p><\/div><\/div><\/td>

155<\/p><\/div><\/div><\/td>

770<\/p><\/div><\/div><\/td>

500<\/p><\/div><\/div><\/td><\/tr>

Frequency (cycles \/min)<\/strong><\/p><\/div><\/div><\/td>

40<\/p><\/div><\/div><\/td>

30<\/p><\/div><\/div><\/td>

25<\/p><\/div><\/div><\/td>

12<\/p><\/div><\/div><\/td>

13<\/p><\/div><\/div><\/td><\/tr>

I\/E Ratio<\/strong><\/p><\/div><\/div><\/td>

1:3<\/p><\/div><\/div><\/td>

1:3<\/p><\/div><\/div><\/td>

1:2<\/p><\/div><\/div><\/td>

1:2<\/p><\/div><\/div><\/td>

1:2<\/p><\/div><\/div><\/td><\/tr>

Minute Volume (ml)<\/strong><\/p><\/div><\/div><\/td>

1000<\/p><\/div><\/div><\/td>

1500<\/p><\/div><\/div><\/td>

3875<\/p><\/div><\/div><\/td>

9240<\/p><\/div><\/div><\/td>

6500<\/p><\/div><\/div><\/td><\/tr><\/tbody><\/table>\n<\/div>\n\n

\u5c3d\u7ba1\u5b58\u5728\u8fd9\u4e9bDDU\u6d4b\u8bd5\u8981\u6c42\uff0c\u4f46\u7528\u4e8e\u6d4b\u91cf\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03 (APSD) \u7684\u836f\u5178\u65b9\u6cd5\u59cb\u7ec8\u8981\u6c42\u91c7\u7528\u65b9\u6ce2\u6c14\u6d41\u66f2\u7ebf\u3002<\/p>\n

\u539f\u56e0\u662f\u4ec0\u4e48\uff1f\u7528\u4e8e\u6d4b\u5b9aAPSD\u7684\u591a\u7ea7\u649e\u51fb\u5668\u9700\u8981\u6052\u5b9a\u7684\u6c14\u6d41\u901f\u7387\uff0c\u8fd9\u4f7f\u5f97\u5e94\u7528\u53ef\u53d8\u547c\u5438\u6a21\u5f0f\u53d8\u5f97\u590d\u6742\u3002<\/p>\n <\/div>\n <\/div>\n\n \n <\/div>\n <\/section>\n\n\n\n

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\u5f15\u5165\u62df\u771fAPSD<\/strong><\/h5>\n

FDA\u8fd1\u671f\u53d1\u5e03\u7684\u4ea7\u54c1\u7279\u5b9a\u6307\u5357 (PSG) \u5f15\u5165\u4e86\u62df\u771fAPSD\u6d4b\u91cf\u6982\u5ff5\uff0c\u8fd9\u662f\u5bf9\u73b0\u884c\u836f\u5178\u6d4b\u5b9a\u65b9\u6cd5\u7684\u5b8c\u5584\u3002<\/p>\n

\u6d4b\u91cf\u62df\u771fAPSD\u7684\u5173\u952e\u5728\u4e8e\u91c7\u7528\uff1a<\/p>\n