{"id":61207,"date":"2025-09-10T07:18:37","date_gmt":"2025-09-10T06:18:37","guid":{"rendered":"https:\/\/copley1.wpenginepowered.com\/?post_type=blog_type&#038;p=61207"},"modified":"2026-04-07T12:12:04","modified_gmt":"2026-04-07T11:12:04","slug":"%e6%8f%90%e9%ab%98oindp%e6%b5%8b%e8%af%95%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%b8%e5%85%b3%e6%80%a7%ef%bc%9a%e8%a7%a3%e6%9e%90%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bb%a5%e5%8f%8a-2","status":"publish","type":"blog_type","link":"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/%e6%8f%90%e9%ab%98oindp%e6%b5%8b%e8%af%95%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%b8%e5%85%b3%e6%80%a7%ef%bc%9a%e8%a7%a3%e6%9e%90%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bb%a5%e5%8f%8a-2\/","title":{"rendered":"\u6bcf\u4f4dOINDP\u5206\u6790\u5e08\u5e94\u638c\u63e1\u7684\u4e94\u5927\u5173\u952e\u672f\u8bed"},"content":{"rendered":"<div class=\"entry-content\">\n\n    <section id=\"block-block_64f0b7b51e737\" class=\"blog-intro\">\n        <div class=\"row\">\n\n            <div class=\"col-12\">\n                <div id=\"content\">\n                    <h6>OINDP\u6d4b\u8bd5\u62e5\u6709\u5176\u72ec\u7279\u7684\u672f\u8bed\u4f53\u7cfb\uff0c\u5176\u4e2d\u67d0\u4e9b\u672f\u8bed\u5e38\u4ee4\u65b0\u5165\u884c\u8005\u611f\u5230\u56f0\u60d1\u3002\u4ee5\u4e0b\u662f\u4e00\u4e9b\u5e38\u89c1\u77ed\u8bed\u7684\u6c47\u603b\u3002<\/h6>\n<p>\u6240\u6709\u79d1\u5b66\u9886\u57df\u90fd\u6709\u5176\u4e13\u5c5e\u672f\u8bed\uff0c\u5438\u5165\u836f\u7269\u9012\u9001\u9886\u57df\u4ea6\u4e0d\u4f8b\u5916\u3002\u8d44\u6df1OINDP\u5206\u6790\u5e08\u7ecf\u5e38\u4f7f\u7528\u8be5\u9886\u57df\u7279\u6709\u7684\u672f\u8bed\uff0c\u6216\u662f\u201c\u501f\u7528\u201d\u5e76\u4e13\u95e8\u5e94\u7528\u7684\u672f\u8bed\u3002\u65b0\u5165\u884c\u8005\u5f88\u5feb\u5c31\u4f1a\u4f7f\u7528\u76f8\u540c\u672f\u8bed (\u901a\u5e38\u4ee5\u7f29\u5199\u5f62\u5f0f\u51fa\u73b0)\uff0c\u6709\u65f6\u751a\u81f3\u6ca1\u6709\u5b8c\u5168\u7406\u89e3\u5176\u5177\u4f53\u542b\u4e49\u6216\u5f71\u54cd\u3002<\/p>\n<p>\u5728\u672c\u535a\u6587\u4e2d\uff0c\u6211\u4eec\u5c06\u6df1\u5165\u63a2\u8ba8\u6bcf\u4f4d\u5438\u5165\u5236\u5242\u6d4b\u8bd5\u5206\u6790\u5e08\u5747\u5e94\u638c\u63e1\u7684\u4e94\u4e2a\u6838\u5fc3\u672f\u8bed\u3002\u6211\u4eec\u65e8\u5728\u63d0\u4f9b\u5168\u65b0\u89c6\u89d2\u6216\u91cd\u8981\u80cc\u666f\u4fe1\u606f\uff0c\u5373\u4fbf\u662f\u8d44\u6df1\u4e13\u4e1a\u4eba\u58eb\u4e5f\u53ef\u80fd\u4e3a\u4e4b\u8033\u76ee\u4e00\u65b0\u3002\u65e0\u8bba\u60a8\u662f\u521d\u6d89\u5438\u5165\u5236\u5242\u836f\u54c1\u6d4b\u8bd5\u9886\u57df\uff0c\u8fd8\u662f\u5e0c\u671b\u7cbe\u8fdb\u4e13\u4e1a\u6280\u80fd\uff0c\u91cd\u6e29\u57fa\u7840\u77e5\u8bc6\u90fd\u5927\u6709\u88e8\u76ca\u3002<\/p>\n<h5>APSD &#8211; \u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03<\/h5>\n<p><strong>\u5b9a\u4e49<\/strong>\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u662f\u6839\u636e\u9897\u7c92\u7269\u5728\u79fb\u52a8\u6c14\u6d41\u4e2d\u7684\u884c\u4e3a\u65b9\u5f0f\u6765\u91cf\u5316\u5176\u76f4\u5f84\u7684\u53c2\u6570\u3002\u7ecf\u53e3\u5438\u5165\u4ea7\u54c1\u5242\u91cf\u4e2d\u51e0\u4e4e\u4e0d\u5b58\u5728\u7c92\u5f84\u5b8c\u5168\u76f8\u540c\u7684\u9897\u7c92\u7269\uff0c\u56e0\u6b64\u6211\u4eec\u62a5\u544a\u7684\u662f\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03 (APSD)\uff0c\u800c\u975e\u5355\u4e00\u7684\u6570\u503c\u3002APSD\u663e\u793a\u4e86\u6837\u54c1\u5728\u8d28\u91cf\u57fa\u7840\u4e0a\u6309\u7c92\u5f84\u5206\u5e03\u7684\u60c5\u51b5\uff0c\u5373\u5728\u6574\u4e2a\u7c92\u5f84\u8303\u56f4\u5185\uff0c\u5404\u7c92\u5f84\u5206\u7ea7\u6240\u542b\u7684\u9897\u7c92\u7269\u8d28\u91cf\u5206\u5e03\u60c5\u51b5\u3002<\/p>\n                <\/div>\n                            <\/div>\n\n            \n                    <\/div>\n    <\/section>\n\n\n\n    <section id=\"block-block_68bf238775939\" class=\"blog-intro\">\n        <div class=\"row\">\n\n            <div class=\"col-12\">\n                <div id=\"content\">\n                    <p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"209\" class=\"alignnone size-medium wp-image-61404\" src=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-800x209.jpg.webp\" alt=\"Aerodynamic Diameter\" srcset=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-800x209.jpg.webp 800w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-1200x313.jpg.webp 1200w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-768x201.jpg.webp 768w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-1536x401.jpg.webp 1536w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter-300x78.jpg.webp 300w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/09\/Aerodynamic-Diameter.jpg.webp 1845w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><br \/>\n<em>\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u6216\u76f4\u5f84\u53d7\u9897\u7c92\u7269\u5927\u5c0f\u548c\u5f62\u72b6\u5171\u540c\u5f71\u54cd\uff0c\u4f46\u5173\u952e\u5728\u4e8e\u5b83\u51b3\u5b9a\u4e86\u9897\u7c92\u7269\u5728\u7a7a\u6c14\u4e2d\u7684\u884c\u4e3a\u65b9\u5f0f\uff0c\u56e0\u6b64\u5bf9OINDP\u5177\u6709\u9ad8\u5ea6\u76f8\u5173\u6027\u3002<\/em><\/p>\n<p><strong><br \/>\n\u91cd\u8981\u6027<\/strong>\u6b63\u5982\u6211\u4eec\u5728<a href=\"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/%e4%ba%86%e8%a7%a3%e5%a4%9a%e7%ba%a7%e6%92%9e%e5%87%bb%e5%99%a8%e6%95%b0%e6%8d%ae%ef%bc%9a%e9%9c%80%e8%a6%81%e6%b5%8b%e9%87%8f%e5%93%aa%e4%ba%9b%e6%8c%87%e6%a0%87%ef%bc%8c%e4%b8%ba%e4%bb%80%e4%b9%88\/\" target=\"_blank\" rel=\"noopener\">\u4e4b\u524d\u7684\u535a\u6587<\/a>\u4e2d\u6240\u8ba8\u8bba\u7684\uff0c\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03\u662f\u6240\u6709\u53e3\u670d\u5438\u5165\u5236\u5242 (OIP) \u7684\u4e00\u9879\u6027\u80fd\u6307\u6807\u3002<\/p>\n<p><strong>\u6ce8\u610f\u4e8b\u9879<\/strong>\uff1a\u5c3d\u7ba1APSD\u662f\u5e38\u89c1\u672f\u8bed\uff0c\u4ecd\u6709\u51e0\u70b9\u91cd\u8981\u4e8b\u9879\u503c\u5f97\u7279\u522b\u5f3a\u8c03\uff1a<\/p>\n<ul>\n<li><em><strong>\u201c\u7a7a\u6c14\u52a8\u529b\u5b66\u201d\u81f3\u5173\u91cd\u8981<\/strong><\/em>\u3002<a href=\"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/apsd%e5%af%b9%e6%af%94gpsd%ef%bc%9a%e5%9b%a0%e4%b8%ba%e5%b9%b6%e9%9d%9e%e6%89%80%e6%9c%89%e7%b2%92%e5%be%84%e6%8c%87%e6%a0%87%e9%83%bd%e6%98%af%e7%ad%89%e5%90%8c%e7%9a%84%ef%bc%81\/\" target=\"_blank\" rel=\"noopener\">APSD\u4e0e\u51e0\u4f55\u7c92\u5f84\u5206\u5e03 (GPSD) <\/a>(\u901a\u5e38\u901a\u8fc7\u6fc0\u5149\u884d\u5c04\u6cd5\u6d4b\u91cf) \u6216\u4efb\u4f55\u5176\u4ed6\u65b9\u5f0f\u6d4b\u91cf\u7684PSD\u5747\u4e0d\u76f8\u540c\u3002\u7c92\u5f84\u6d4b\u91cf\u6280\u672f\u901a\u8fc7\u6d4b\u91cf\u9897\u7c92\u7269\u884c\u4e3a\u7684\u4e0d\u540c\u65b9\u9762\u6765\u751f\u6210\u6570\u636e\u3002\u6211\u4eec\u9009\u62e9APSD\uff0c\u662f\u56e0\u4e3a\u8fd9\u9879\u6307\u6807\u4e0e\u9897\u7c92\u7269\u5728\u6c14\u6d41\u4e2d\u7684\u884c\u4e3a\u65b9\u5f0f\u76f8\u5173\u8054\uff0c\u8fdb\u800c\u51b3\u5b9a\u4e86\u5b83\u4eec\u5982\u4f55\u968f\u7740\u5438\u6c14\u88ab\u5438\u5165\u4eba\u4f53\u3002\u8fd9\u5c31\u4f7f\u6211\u4eec\u60f3\u5230\u4e86\u4e00\u70b9&#8230;&#8230;<\/li>\n<li><em><strong>\u591a\u7ea7\u649e\u51fb\u5668\u5185\u90e8\u7684\u7a7a\u6c14\u52a8\u529b\u5b66\u7279\u6027\u51b3\u5b9a\u4e86\u6d4b\u91cf\u7cbe\u5ea6<\/strong><\/em>\u3002\u6211\u4eec\u901a\u8fc7\u591a\u7ea7\u649e\u51fb\u5668\u6cd5\u51c6\u786e\u6d4b\u91cf\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03\u7684\u80fd\u529b\uff0c\u53d6\u51b3\u4e8e\u5bf9\u649e\u51fb\u5668\u5185\u7a7a\u6c14\u52a8\u529b\u5b66\u673a\u5236\u7684\u7cbe\u786e\u63a7\u5236\u3002\u8fd9\u4e3b\u8981\u5305\u62ec\u4e09\u4e2a\u65b9\u9762\uff1a<\/li>\n<\/ul>\n<ul>\n<li>\u9075\u7167\u7cbe\u5bc6\u516c\u5dee\u5236\u9020\u5e76\u7ecf\u8fc7\u6821\u51c6\u7684\u591a\u7ea7\u649e\u51fb\u5668\u3002<\/li>\n<li>\u901a\u8fc7\u4f8b\u884c\u7ef4\u62a4\u4fdd\u6301\u539f\u59cb\u5c3a\u5bf8\u3002<\/li>\n<li>\u5728\u6bcf\u6b21\u6d4b\u91cf\u8fc7\u7a0b\u4e2d\u7cbe\u786e\u63a7\u5236\u6c14\u6d41\u3002<\/li>\n<li><strong><em>\u5bf9\u4e8eOIP\uff0cAPSD\u6d4b\u91cf\u4e0e\u6eb6\u51fa\u5ea6\u5b58\u5728\u5173\u8054<\/em><\/strong>\u3002\u82e5\u8981\u7406\u89e3\u88ab\u5438\u5165\u9897\u7c92\u7269\u5982\u4f55\u6eb6\u51fa\uff0c\u5219\u9700\u4ece\u53ef\u5438\u5165\u7c92\u5b50\u5f00\u59cb\u5206\u6790\u3002\u5c3d\u7ba1\u7c92\u5f84\u4e0e\u6eb6\u51fa\u5ea6\u4e4b\u95f4\u7684\u666e\u904d\u76f8\u5173\u6027\u5df2\u5e7f\u4e3a\u4eba\u77e5\uff0c\u4f46\u9700\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u7684\u662f\uff1a\u5728\u80fd\u591f\u4ee3\u8868\u80ba\u90e8\u73af\u5883\u7684\u6761\u4ef6\u4e0b\uff0c\u53ef\u5438\u5165\u7c92\u5b50\u662f\u5982\u4f55\u6eb6\u51fa\u7684\u3002\u591a\u7ea7\u649e\u51fb\u5668\u6cd5\u4e3a\u5206\u79bb\u8be5\u7c92\u5f84\u8303\u56f4\u9897\u7c92\u7269\u63d0\u4f9b\u4e86\u7edd\u4f73\u8d77\u70b9\u3002<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<h5>IVIVC &#8211; <em>\u4f53\u5916-\u4f53\u5185<\/em>\u76f8\u5173\u6027<\/h5>\n<p><strong>\u5b9a\u4e49<\/strong>IVIVC\u63cf\u8ff0\u4e86\u5b9e\u9a8c\u5ba4\u6d4b\u91cf\u7ed3\u679c\u4e0e\u4f53\u5185\u884c\u4e3a\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n<p><strong>\u91cd\u8981\u6027<\/strong>\u5728\u5f00\u53d1\u5404\u7c7b\u5242\u578b\u7684\u836f\u54c1\u65f6\uff0c\u5efa\u7acb\u5f3a\u5927\u7684IVIVC\u53ef\u4ee5\u5b9e\u73b0\u66f4\u6709\u610f\u4e49\u7684<em>\u4f53\u5916<\/em>\u6d4b\u8bd5\uff0c\u51cf\u5c11\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4f9d\u8d56\uff0c\u5e76\u52a0\u901f\u4ea7\u54c1\u5f00\u53d1\u8fdb\u7a0b\u3002<\/p>\n<p><strong>\u6ce8\u610f\u4e8b\u9879<\/strong>\uff1a\u5bf9\u4e8eOINDP\u800c\u8a00\uff0c\u5efa\u7acb\u7a33\u5065\u7684IVIVC\u4ecd\u662f\u4e00\u9879\u91cd\u5927\u6311\u6218\uff0c\u6b63\u5982\u6211\u4eec\u5728<a href=\"https:\/\/www.copleyscientific.com\/zh-hans\/blogs\/%e6%8f%90%e9%ab%98oindp%e6%b5%8b%e8%af%95%e7%9a%84%e4%b8%b4%e5%ba%8a%e7%9b%b8%e5%85%b3%e6%80%a7%ef%bc%9a%e8%a7%a3%e6%9e%90%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bb%a5%e5%8f%8a\/\" target=\"_blank\" rel=\"noopener\">\u4e4b\u524d\u7684\u535a\u6587\u4e2d<\/a>\u6240\u5f3a\u8c03\u7684\u90a3\u6837\u3002<\/p>\n<p><strong>\u539f\u56e0\u662f\u4ec0\u4e48\uff1f<\/strong>\u751f\u7406\u5b66\u662f\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff1b\u836f\u7269\u8fdb\u5165\u4f53\u5faa\u73af\u7684\u9014\u5f84\u6f2b\u957f\u800c\u590d\u6742\u3002\u4f8b\u5982\uff0c\u80ba\u90e8\u6709\u8bb8\u591a\u76f4\u5f84\u9010\u6e10\u51cf\u5c0f\u7684\u5206\u652f\u901a\u9053\uff1b\u5e76\u4e14\u5b58\u5728\u5c11\u91cf\u6db2\u4f53\u3002\u800c\u9f3b\u9ecf\u819c\u7ea4\u6bdb\u6e05\u9664\u7cfb\u7edf\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u9632\u5fa1\u673a\u5236\u3002<\/p>\n<p>OINDP\u7684\u76ee\u6807\u901a\u5e38\u662f\u5b9e\u73b0\u5c40\u90e8\u8d77\u6548\uff0c\u56e0\u6b64\u88ab\u5438\u5165\u9897\u7c92\u7269\u6c89\u79ef\u540e\u7684\u5f52\u5bbf\u6d89\u53ca\u7684\u662f\u5b89\u5168\u95ee\u9898\uff0c\u800c\u975e\u7597\u6548\u95ee\u9898\u3002<br \/>\n\u4f46\u8fd9\u79cd\u5c40\u9762\u6b63\u5728\u6539\u53d8\u3002<\/p>\n<p>\u968f\u7740\u75ab\u82d7\u548c\u7cfb\u7edf\u7597\u6cd5\u7684\u5f00\u53d1\uff0c\u66f4\u5168\u9762\u5730\u4e86\u89e3<em>\u4f53\u5185<\/em>\u8def\u5f84\u6b63\u53d8\u5f97\u6108\u53d1\u5173\u952e\u3002\u8fd9\u4e00\u8f6c\u53d8\u6b63\u63a8\u52a8\uff1a<\/p>\n<ul>\n<li>\u66f4\u5177\u751f\u7406\u5b66\u76f8\u5173\u6027\u7684<em>\u4f53\u5916<\/em>\u65b9\u6cd5<\/li>\n<li>\u751f\u7406\u836f\u4ee3\u52a8\u529b\u5b66 (PBPK) \u6a21\u578b\u7684\u8fdb\u6b65<\/li>\n<\/ul>\n<p>\u6211\u4eec\u8d8a\u80fd\u4e3aOINDP\u5efa\u7acb\u7a33\u5065\u7684IVIVC\uff0c\u5c31\u8d8a\u80fd\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u5feb\u901f\u7ecf\u6d4e\u5730\u5f00\u5c55\u5b9e\u9a8c\u3002<\/p>\n<p>\u5373\u4f7f\u662f\u5c40\u90e8\u4f5c\u7528\u4ea7\u54c1\uff0c\u4ecd\u6709\u6539\u8fdb\u7a7a\u95f4\u3002\u6211\u4eec\u6709\u671b\u901a\u8fc7\u8c03\u4f18\u7c92\u5f84\u5c0f\u4e8e5 \u00b5m\u7684\u836f\u7269\u5242\u91cf\uff0c\u5b9e\u73b0\u5728\u80ba\u90e8\u4e0d\u540c\u533a\u57df\u66f4\u6709\u6548\u7684\u6c89\u79ef\uff0c\u7ee7\u800c\u63d0\u5347\u7597\u6548\u3002\u53ea\u8981\u6211\u4eec\u80fd\u591f\u6df1\u5316\u5bf9<em>\u4f53\u5185<\/em>\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u5c31\u80fd\u505a\u5230\u8fd9\u4e00\u70b9\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5bf9\u4e8e\u4eff\u5236\u836f\u800c\u8a00\uff0c\u53ea\u9700\u8fdb\u884c\u6781\u5c11\u91cf\u7684<em>\u4f53\u5185<\/em>\u6d4b\u8bd5\u5373\u53ef\u8bc1\u660e\u5176\u751f\u7269\u7b49\u6548\u6027\u3002<\/p>\n                <\/div>\n                            <\/div>\n\n            \n                    <\/div>\n    <\/section>\n\n\n\n    <section id=\"block-block_6735fe9039f6e\" class=\"blog-intro\">\n        <div class=\"row\">\n\n            <div class=\"col-12\">\n                <div id=\"content\">\n                    <h5>FPD &#8211; \u5fae\u7ec6\u7c92\u5b50\u5242\u91cf<\/h5>\n<p><strong>\u5b9a\u4e49<\/strong>\u5373\u5242\u91cf\u4e2d\u7684\u53ef\u5438\u5165\u7c92\u5b50\u8d28\u91cf\uff0c\u901a\u5e38\u6307\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5c0f\u4e8e5 \u00b5m\u7684\u9897\u7c92\u7269\u3002<\/p>\n<p><strong>\u91cd\u8981\u6027<\/strong>5 \u00b5m\u901a\u5e38\u88ab\u89c6\u4e3a\u80ba\u90e8\u6c89\u79ef\u7684\u7c92\u5f84\u4e0a\u9650\uff0c\u56e0\u6b64FPD\u662fOIP\u4e2d\u6700\u5e38\u62a5\u544a\u7684\u6307\u6807\u4e4b\u4e00\u3002<\/p>\n<p><strong>\u6ce8\u610f\u4e8b\u9879<\/strong>\uff1a\u63d0\u9ad8FPD\u53ef\u4f7f\u836f\u7269\u66f4\u6709\u6548\u5730\u5b9e\u73b0\u80ba\u90e8\u7ed9\u836f\uff0c\u8fdb\u800c\u63d0\u5347\u4e34\u5e8a\u7597\u6548\u3002\u901a\u8fc7\u786e\u8ba4FPD\u7b49\u6548\u6027\uff0c\u5c31\u80fd\u4fdd\u8bc1\u6279\u6b21\u95f4\u53ef\u6bd4\u6027\u3002\u5bf9\u5417\uff1f<\/p>\n<p>\u5176\u5b9e\u8fd9\u79cd\u8bf4\u6cd5\u4e0d\u5c3d\u7136\u3002\u4eba\u4eec\u5f88\u5bb9\u6613\u8ba4\u4e3aFPD\u80fd\u8bf4\u660e\u4e00\u5207\uff0c\u4f46\u4e8b\u5b9e\u5e76\u975e\u5982\u6b64\u3002OIP\u7684APSD (\u6837\u54c1\u95f4\u3001\u6279\u6b21\u95f4\u53ca\u4ea7\u54c1\u95f4) \u53ef\u80fd\u5b58\u5728\u5dee\u5f02\uff0c\u4e3b\u8981\u4f53\u73b0\u5728\u4e24\u4e2a\u65b9\u9762\uff1a<\/p>\n<p>1. \u7ec6\u9897\u7c92\u7269\u548c\/\u6216\u7c97\u9897\u7c92\u7269\u7684\u542b\u91cf\u53ef\u80fd\u53d1\u751f\u53d8\u5316\uff0c\u5373\u7c92\u5f84\u5206\u5e03\u7684\u5f62\u72b6\u53ef\u80fd\u53d1\u751f\u53d8\u5316\u6216<br \/>\n2. <b><i>\u603b<\/i><\/b>\u8d28\u91cf\u53d1\u751f\u53d8\u5316\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"135\" class=\"alignnone size-medium wp-image-61275\" src=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-800x135.png.webp\" alt=\"APSD graphs\" srcset=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-800x135.png.webp 800w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-1200x202.png.webp 1200w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-768x129.png.webp 768w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-1536x259.png.webp 1536w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs-300x51.png.webp 300w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/APSD-graphs.png.webp 1562w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<p style=\"text-align: center;\"><em>APSD\u5728\u7c92\u5f84 (\u5de6\u56fe\u548c\u4e2d\u56fe) \u6216\u6536\u96c6\u8d28\u91cf (\u5de6\u56fe\u548c\u53f3\u56fe) \u65b9\u9762\u53ef\u80fd\u5b58\u5728\u5dee\u5f02<\/em><\/p>\n                <\/div>\n                            <\/div>\n\n            \n                    <\/div>\n    <\/section>\n\n\n\n    <section id=\"block-block_68a84d5c4b691\" class=\"blog-intro\">\n        <div class=\"row\">\n\n            <div class=\"col-12\">\n                <div id=\"content\">\n                    <p>\u7531\u4e8eFPD\u5b9a\u4e49\u4e86\u53ef\u5438\u5165\u7c92\u5b50\u8d28\u91cf\uff0c\u5b83\u6781\u5176\u64c5\u957f\u6355\u6349\u6700\u540e\u4e00\u79cd\u7c7b\u578b\u7684\u53d8\u5316\u3002\u4f465 \u00b5m\u4ee5\u4e0b\u533a\u57df\u7684\u7c92\u5f84\u5206\u5e03\u53d8\u5316\u5e76\u4e0d\u663e\u8457\u3002\u4e00\u79cd\u4ea7\u54c1\u53ef\u80fd\u6bd4\u53e6\u4e00\u79cd\u4ea7\u54c1\u542b\u6709\u66f4\u591a\u7684\u7ec6\u9897\u7c92\u7269\uff0c\u4f46\u4ecd\u5177\u6709\u76f8\u540c\u7684FPD\u503c (\u53c2\u89c1\u4e0a\u56fe\u4e2d\u95f4\u56fe\u8868)\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cFPD\u7b49\u6548\u6027\u53ef\u80fd\u5e76\u4e0d\u7b49\u540c\u4e8e\u751f\u7269\u7b49\u6548\u6027\u3002<\/p>\n<p>\u603b\u4e4b\uff0cFPD\u6781\u5177\u4ef7\u503c\uff0c\u4f46\u4ec5\u51ed\u8fd9\u4e00\u79cd\u6307\u6807\u4e0d\u8db3\u4ee5\u6355\u6349\u60a8\u53ef\u80fd\u9700\u8981\u5173\u6ce8\u7684\u53d8\u5316\u3002\u5982\u9700\u8fdb\u884c\u5168\u65b9\u4f4d\u6d1e\u5bdf\uff0c\u5e94\u7ed3\u5408\u5176\u4ed6APSD\u6307\u6807\u8fdb\u884c\u89e3\u8bfb\u3002<\/p>\n<p>\u00a0<\/p>\n<h5>EDA &#8211; \u9ad8\u6548\u6570\u636e\u5206\u6790<\/h5>\n<p><strong>\u5b9a\u4e49<\/strong>EDA\u652f\u6301\u5c42\u7ea7\u5206\u7ec4\uff0c\u6240\u5305\u542b\u7684\u7ec4\u5206\u6570\u91cf\u66f4\u5c11\uff0c\u56e0\u6b64\u80fd\u591f\u66f4\u9ad8\u6548\u5730\u5229\u7528\u591a\u7ea7\u649e\u51fb\u5668\u7684\u5168\u90e8\u6d4b\u91cf\u6570\u636e\u3002<\/p>\n<p><strong>\u91cd\u8981\u6027<\/strong>\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u4ec5\u7b80\u5316\u4e86\u6570\u636e\u5206\u6790\u6d41\u7a0b\uff0c\u540c\u65f6\u8fd8\u80fd\u63d0\u9ad8\u7cbe\u5ea6\u3002<\/p>\n<p><strong>\u6ce8\u610f\u4e8b\u9879<\/strong>\uff1a\u901a\u5e38\uff0c\u6570\u636e\u5206\u7ec4\u4f1a\u964d\u4f4e\u5206\u8fa8\u7387\u3002\u4f46EDA\u4e0d\u4f1a\u3002\u76f8\u53cd\uff0c\u5b83\u53ef\u4ee5\u6700\u5927\u7a0b\u5ea6\u51cf\u5c11\u591a\u7ea7\u649e\u51fb\u5668\u6570\u636e\u5206\u6790\u4e2d\u67d0\u4e9b\u6f5c\u5728\u7684\u3001\u4f46\u65e0\u6cd5\u907f\u514d\u7684\u8bef\u5dee\u548c\u5c40\u9650\u6027\u3002<\/p>\n<p>\u5e38\u89c4OIP\u7684APSD\u7279\u6027\u4f1a\u5bfc\u81f4\u591a\u7ea7\u649e\u51fb\u5668\u9996\u5c3e\u4e24\u7ea7\u4e0a\u7684\u836f\u7269\u6c89\u79ef\u91cf\u76f8\u5bf9\u4e8e\u4e2d\u95f4\u5404\u7ea7\u8981\u5c11\u3002\u6839\u636e\u6240\u7528\u5206\u6790\u8bbe\u5907\u7684\u7075\u654f\u5ea6\uff0c\u53ef\u80fd\u4f1a\u5bfc\u81f4\u68c0\u6d4b\u56f0\u96be\uff0c\u4ea7\u751f\u65e0\u6548\u7ed3\u679c\u6216\u91cd\u5927\u8bef\u5dee\u3002\u589e\u52a0\u4fc3\u52a8\u6b21\u6570\u53ef\u89e3\u51b3\u6b64\u95ee\u9898\uff0c\u4f46\u4f1a\u5ef6\u957f\u5b9e\u9a8c\u65f6\u95f4\u3001\u6d88\u8017\u66f4\u591a\u836f\u54c1\u3001\u53ef\u80fd\u589e\u52a0\u53ef\u53d8\u6027\uff0c\u5e76\u5bfc\u81f4\u4e2d\u95f4\u5c42\u7ea7\u8fc7\u8f7d\u3002\u786e\u5b9a\u8fbe\u5230\u68c0\u6d4b\u9650\u503c\u6240\u9700\u7684\u4fc3\u52a8\u6b21\u6570\uff0c\u540c\u65f6\u53c8\u907f\u514d\u8fc7\u8f7d\uff0c\u8fd9\u662f\u4e00\u9879\u81f3\u5173\u91cd\u8981\u7684\u5e73\u8861\u827a\u672f\u3002<\/p>\n<p>\u5982\u679c\u5bf9\u5c42\u7ea7\u8fdb\u884c\u5206\u7ec4 (\u4f8b\u5982\u901a\u8fc7EDA)\uff0c\u76f8\u5bf9\u4e8e\u5355\u4e2a\u5c42\u7ea7\uff0c\u6bcf\u7ec4\u5c42\u7ea7\u7684\u4ea7\u54c1\u8d28\u91cf\u5c06\u66f4\u5927\u3002\u8fd9\u6837\uff0c\u6211\u4eec\u4e0d\u4ec5\u80fd\u591f\u6700\u5927\u7a0b\u5ea6\u51cf\u5c11\u4fc3\u52a8\u6b21\u6570\uff0c\u8fd8\u80fd\u751f\u6210\u9700\u8981\u5173\u6ce8\u7684\u7cbe\u786e\u6307\u6807\u3002\u8bdd\u867d\u5982\u6b64\uff0c\u6211\u4eec\u9700\u8981\u786e\u4fddEDA\u6307\u6807\u7684\u4f7f\u7528\u4e0d\u4f1a\u63a9\u76d6\u7279\u5b9a\u7c92\u5f84\u8303\u56f4\u5185\u7684\u5173\u952e\u53d8\u5316\uff0c\u6b63\u5982\u6211\u4eec\u6240\u89c1\uff0cFPD\u6280\u672f\u5728\u5206\u67905 \u00b5m\u4ee5\u4e0b\u9897\u7c92\u7269\u65f6\u4fbf\u5b58\u5728\u6b64\u7c7b\u95ee\u9898\u3002<\/p>\n<p>\u603b\u4e4b\uff0cEDA\u80fd\u591f\u7cbe\u7b80\u6570\u636e\u5206\u6790\u6d41\u7a0b\uff0c\u5e76\u652f\u6301\u91c7\u7528<a href=\"https:\/\/www.copleyscientific.com\/zh-hans\/%e5%90%b8%e5%85%a5%e5%88%b6%e5%89%82%e8%af%95%e9%aa%8c\/%e7%89%b9%e6%ae%8a%e5%ba%94%e7%94%a8\/%e5%86%b2%e5%87%bb%e5%99%a8%e7%bc%a9%e5%86%99-aim\/%e5%bf%ab%e9%80%9f%e7%ad%9b%e9%80%89%e5%ae%89%e5%be%92%e7%94%9f-fsa\/\" target=\"_blank\" rel=\"noopener\">\u7b80\u5316\u649e\u51fb\u5668\u6cd5 (AIM)<\/a>\uff0c\u4ece\u800c\u7f29\u77ed\u5206\u6790\u65f6\u95f4\u3002\u540c\u65f6\uff0c\u5b83\u80fd\u63d0\u5347\u6570\u636e\u7cbe\u5ea6\u548c\u4ef7\u503c\uff0c\u66f4\u8f7b\u677e\u5730\u5b9e\u73b0\u4ea7\u54c1\u7684\u6709\u6548\u5bf9\u6bd4\u3002\u8fd9\u79cd\u53cc\u8d62\u5c40\u9762\u65e2\u975e\u540c\u5bfb\u5e38\uff0c\u53c8\u6781\u5177\u4ef7\u503c\u3002<\/p>\n<p>\u00a0<\/p>\n<h5>\u4e34\u754c\u6d41\u91cf<\/h5>\n<p><strong>\u5b9a\u4e49\uff1a<\/strong>\u5f53\u6c14\u4f53\u9ad8\u901f\u901a\u8fc7\u72ed\u7a84\u5f00\u53e3\uff0c\u5176\u901f\u5ea6\u8fbe\u5230 (\u5468\u56f4\u73af\u5883\u6e29\u5ea6\u4e0e\u538b\u529b\u6761\u4ef6\u4e0b) \u58f0\u901f\u65f6\uff0c\u5c31\u4f1a\u4ea7\u751f\u4e34\u754c\u6d41\u91cf\u3002\u6b64\u65f6\uff0c\u65e0\u8bba\u5f00\u53e3\u4e0b\u6e38\u53d1\u751f\u4ec0\u4e48\uff0c\u6d41\u91cf\u90fd\u4fdd\u6301\u4e0d\u53d8\u3002\u8fd9\u5c31\u662f\u6240\u8c13\u7684\u201c\u963b\u585e\u6d41\u201d\uff0c\u8fd9\u610f\u5473\u7740\u901a\u8fc7\u5f00\u53e3\u7684\u7a7a\u6c14\u91cf\u4ec5\u7531\u4e0a\u6d41\u4fa7\u7684\u538b\u529b\u6240\u63a7\u5236\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u65e0\u8bba\u4e0b\u6e38\u53d1\u751f\u4ec0\u4e48\u53d8\u5316 (\u4f8b\u5982\u771f\u7a7a\u538b\u529b\u53d8\u5316)\uff0c\u6d41\u91cf\u90fd\u4fdd\u6301\u7a33\u5b9a\u3002<\/p>\n<p>\u5f53\u5b54\u53e3\u6216\u9600\u95e8\u4e0b\u6e38\u7684\u538b\u529b\u964d\u81f3\u4e0a\u6e38\u538b\u529b\u76840.5\u500d\u6216\u4ee5\u4e0b\u65f6\uff0c\u5373\u8fbe\u5230\u8be5\u4e34\u754c\u70b9\u3002<\/p>\n<p><strong>\u91cd\u8981\u6027<\/strong>\u5728\u5e72\u7c89\u5438\u5165\u5242 (DPI) \u6d4b\u8bd5\u4e2d\uff0c\u5b9e\u73b0\u7a33\u5b9a\u6d41\u91cf\u5c24\u4e3a\u5173\u952e\uff0c\u56e0\u4e3a\u7ed9\u836f\u548c\u5206\u6563\u6027\u80fd\u4e0e\u7a7a\u6c14\u901a\u8fc7\u88c5\u7f6e\u65f6\u7684\u6d41\u52a8\u72b6\u6001\u5bc6\u5207\u76f8\u5173\u3002\u56e0\u6b64\uff0c<\/p>\n<ul>\n<li>\u4e34\u754c\u6d41\u91cf\u662fDPI\u9012\u9001\u5242\u91cf\u5747\u4e00\u6027 (DDU) \u6d4b\u8bd5\u548c\u7a7a\u6c14\u52a8\u529b\u5b66\u7c92\u5f84\u5206\u5e03 (APSD) \u6d4b\u91cf\u7684\u836f\u5178\u8981\u6c42\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/li>\n<li>\u5173\u952e\u6d41\u91cf\u63a7\u5236\u5668\u662fDPI\u6d4b\u8bd5\u88c5\u7f6e\u4e2d\u6807\u51c6\u4e14\u5fc5\u4e0d\u53ef\u5c11\u7684\u7ec4\u6210\u90e8\u5206\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"366\" class=\"alignnone size-medium wp-image-61218\" src=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/Critical-flow-800x366.jpg.webp\" alt=\"Critical flow\" srcset=\"https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/Critical-flow-800x366.jpg.webp 800w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/Critical-flow-768x352.jpg.webp 768w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/Critical-flow-300x137.jpg.webp 300w, https:\/\/www.copleyscientific.com\/wp-content\/smush-webp\/2025\/08\/Critical-flow.jpg.webp 928w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/p>\n<p style=\"text-align: center;\"><em>\u9488\u5bf9DPI\u7684APSD\u6d4b\u91cf\u7cfb\u7edf\u793a\u610f\u56fe\uff1a\u663e\u793a\u4e86\u591a\u7ea7\u649e\u51fb\u5668 (\u53f3\u56fe) \u4e0e\u771f\u7a7a\u6cf5 (\u5de6\u56fe) \u4e4b\u95f4\u7684\u6d41\u91cf\u63a7\u5236\u5668<\/em><\/p>\n                <\/div>\n                            <\/div>\n\n            \n                    <\/div>\n    <\/section>\n\n\n\n    <section id=\"block-block_6735ff1539f8a\" class=\"blog-intro\">\n        <div class=\"row\">\n\n            <div class=\"col-12\">\n                <div id=\"content\">\n                    <p><strong>What to keep in mind: <\/strong>We can see the practical benefits of achieving critical flow conditions by looking at a typical set-up for measuring the APSD of DPIs (see above). In this diagram pressure drop is running from right to left, towards the vacuum pump. Once the downstream pressure (P3) is less than half of the upstream pressure (P2), flow becomes independent of the vacuum side. That means:<\/p>\n<ul>\n<li>Any fluctuations on the vacuum pump side have no impact on mass flow rate<\/li>\n<li>The device is tested under consistent, repeatable conditions<\/li>\n<\/ul>\n<p>In summary, achieving critical flow helps remove a variable from the system, gives you better control over your inhaler testing set-up and ultimately cleaner and more meaningful data.<\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Final Thoughts<\/strong><\/h5>\n<p>Understanding key terminology is more than a box-ticking exercise; it\u2019s about ensuring meaningful, accurate and efficient testing. As the global leader in inhaler testing equipment and expertise, we\u2019re here to help you go beyond compliance to real confidence.<\/p>\n<p>&nbsp;<\/p>\n<p>Make sure you <a href=\"https:\/\/www.copleyscientific.com\/join-our-mailing-list\/\" target=\"_blank\" rel=\"noopener\"><span style=\"color: #833177;\">subscribe to our blog<\/span><\/a> for regular updates on OINDP testing trends, techniques, and expert advice straight to your inbox.<\/p>\n                <\/div>\n                            <\/div>\n\n            \n                    <\/div>\n    <\/section>\n\n<\/div>","protected":false},"excerpt":{"rendered":"\u6bcf\u4f4d\u5438\u5165\u5236\u5242\u6d4b\u8bd5\u5206\u6790\u5e08\u5e94\u638c\u63e1\u7684\u4e94\u5927\u5173\u952e\u672f\u8bed\uff1aAPSD\u3001IVIVC\u3001FPD\u3001EDA\u548c\u4e34\u754c\u6d41\u91cf\u3002","protected":false},"author":3,"featured_media":61418,"menu_order":0,"template":"","meta":{"footnotes":""},"categories":[200],"tags":[282,475,609,610,611],"class_list":["post-61207","blog_type","type-blog_type","status-publish","has-post-thumbnail","hentry","category-200","tag-ddu-ivivc-mdis-bais-dpis-nebulisers-zh-hans-2","tag-475","tag-609","tag-oindp","tag-ivivc"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - 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