Investigating the Impact of Electrostatics on Delivered Dose Uniformity for pMDIs
Benchtop in vitro testing is vital to characterization of performance of medical aerosols and nasal
sprays. Chen et al. previously introduced a plastic idealized nasal geometry, able to mimic average regional deposition of a nasal spray in a set of realistic airway replicas and human subjects, respectively. To test an expanded range of formulations, an Alberta Idealized Nasal Inlet (AINI; Copley Scientific, UK), an aluminum version of the idealized geometry, has been manufactured. The objective of the current study is to compare regional nasal deposition measurements made using the AINI with average in vivo regional deposition data across range of nasal drug products.
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