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Regions represented by the AIT
The drug mass sized by the cascade impactor (impactor sized mass) should ideally be representative of the dose that would actually enter the lungs.
The AIT has a four-region resolution:
- the oral cavity
- the pharynx
- the epiglottis
- the larynx
Knowledge of the portion of the dose captured in the throat is essential to understand the dosage delivery characteristics of a given orally inhaled product (OIP). In many cases, the portion of the dose collected in the throat represents a significant proportion of the delivered dose.
The throat models we offer were developed from extensive research into typical patient populations including information provided by CT and MRI scans, direct observation of living subjects and data in the archival literature. More information and references are available on request.