The Combined Effect of Valve and Spray Orifice Diameters on pMDI Plume Force
Ben Myatt, Barzin Gavtash, Lee Hodges & Andy Cooper
Kindeva Drug Delivery, Loughborough, Leicestershire, UK
Spray force is known to influence patient acceptability of pMDI products & correlates with oropharyngeal deposition, reducing the delivered dose to the patient. pMDI plume force is mainly influenced by formulation propellant, valve volume, and spray orifice diameter – effect of valve orifice diameter on plume force is unknown. The aims of this study were to:
- Characterise plume force of pMDI systems with varying valve and spray orifice diameters and
- Compare modeled plume force predictions against experimental data
Presented at the Respiratory Drug Delivery (RDD) Conference 2022, Orlando, Florida
