Poster: RDD 2022 (Myatt et al)

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The Combined Effect of Valve and Spray Orifice Diameters on pMDI Plume Force    

Ben Myatt, Barzin Gavtash, Lee Hodges & Andy Cooper

Kindeva Drug Delivery, Loughborough, Leicestershire, UK

Spray force is known to influence patient acceptability of pMDI products & correlates with oropharyngeal deposition, reducing the delivered dose to the patient. pMDI plume force is mainly influenced by formulation propellant, valve volume, and spray orifice diameter – effect of valve orifice diameter on plume force is unknown. The aims of this study were to:

  1. Characterise plume force of pMDI systems with varying valve and spray orifice diameters and
  2. Compare modeled plume force predictions against experimental data

Presented at the Respiratory Drug Delivery (RDD) Conference 2022, Orlando, Florida


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