04 December 2024; Nottingham, UK: Copley Scientific, the world’s leading manufacturer and supplier of inhaled product testing equipment, has released a new eBook covering the fundamentals of cascade impaction, a core technique for inhaler testing. Clear, concise and freely available for download, An Introduction to Cascade Impaction is a valuable resource for analysts navigating compendial requirements for the first time, or looking to enhance practice. It is a significant addition to the substantial library of resources Copley already has in place to ensure optimal support for customers.
‘Our latest eBook is a milestone,’ said Jamie Clayton, Managing Director ‘and we’re delighted to have it available for customers. Cascade impaction is a technique of unrivalled value in inhaler testing, but we know its complexities can be a challenge. This new book distils our learnings from more than 35 years of supporting customers in the effective application of cascade impaction across all types of orally inhaled and nasal drug products (OINDPs). We’re confident it will be of considerable value to many analysts.’
Cascade impaction measures the aerodynamic particle size distribution (APSD) of OINDPs generating metrics that are used to assess the likelihood of deposition in the lungs. These metrics are critical quality attributes for inhaled products, measured from R&D through to finished product QC. The eBook covers:
- The underlying aerodynamic principles of cascade impaction and how the technique works in practice.
- Compendial and regulatory requirements for APSD measurement for all types of OINDPs.
- The strengths and limitations of different types of impactors and impingers.
- Test set-ups for metered dose inhalers, dry powder inhalers, nebulisers, soft mist inhalers and all types of nasal drug products.
- Sources of variability and best practice.
Copley’s unrivalled expertise and experience in the manufacture and application of cascade impactors underpins an eBook that is both authoritative and accessible. Download your copy today.
An Introduction to Cascade Impaction
About Copley Scientific
Copley Scientific is widely recognised as the world’s leading manufacturer and supplier of inhaled product testing equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company also supplies equipment for detergent testing.
Copley’s pharmaceutical product range includes testing equipment for all types of orally inhaled and nasal drug products – metered-dose inhalers, dry powder inhalers, nebulisers and nasal products – with a particular focus on solutions for delivered dose uniformity and aerodynamic particle size distribution measurement. It also includes testers for tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories, semisolids and transdermals.
Used from R&D through to QC, this extensive range of equipment is supported by a full validation and aftersales service. Copley works in partnership with specialist distributors, extending localised support across the world. This network provides expert help and training to every customer, directly enhancing the application of all Copley products. www.copleyscientific.com
