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Improving IVIVCs

Making a relatively small investment in systems that enhance the clinical realism of standard pharmacopoeial in-vitro test set-ups for delivered dose uniformity (DDU) testing and aerodynamic particle size distribution (APSD) measurement may help bridge the gap between data collected during QC testing and in vivo performance helping to accelerate and improve R&D.

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Improving IVIVCs

Please select an an item from below for further information about Improving IVIVC’s.

IVIVC Test Systems for DDU and APSD

Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.

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Inhaled Dissolution

In the case of inhaled and nasal drug delivery products, once the drug is deposited to the target site, the absorption or lung uptake, and hence the therapeutic effectiveness of the drug, depends on the active dissolving in the small amounts of aqueous fluid and lung surfactant available.

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Facemask Testing

One of the main factors influencing the amount of inhaled drug available to the patient is the interface between the facemask and the patient. Investigating and defining the effect of a facemask to the product’s DDU and APSD is important for the product development.

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Morphology

Whilst cascade impaction provides a useful indication of where inhaled drug particles are likely to deposit within the respiratory tract, it does not profile the morphological properties of these particles.

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Cold Freon® Effect

Cold Freon®” effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices.

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Related Inhaler Testing Products

For further information about the other products in our inhaler testing range, please select one of the options below.

Delivered Dose Uniformity (DDU)

Our range of Delivered Dose Uniformity (DDU) sampling apparatus are designed to help accurately assess the total amount of emitted drug.

Delivered Dose Uniformity (DDU)

Ancillaries

Optimise inhaler testing workflows with our broad range of supporting equipment required to make up fully-operating test systems for Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) of orally inhaled and nasal drug products (OINDPs).

Ancillaries

Special Applications

Copley Scientific offers a range of testing equipment for additional qualification and validation of orally inhaled and nasal drug products (OINDPs), including assessments of generic drug formulations, inhaled dissolution testing and improving IVIVCs.

Special Applications

Semi-Automation

Take the labour out of inhaler testing with our semi-automated solutions.

Semi-Automation

Aerodynamic Particle Size Distribution (APSD)

Our range of precision engineered cascade impactors measure the size distribution (particle size) of inhaled drug products, providing critical information about where particles in aerosol clouds are likely to be deposited in the lungs following inhalation.