Improving IVIVCs
Please select an an item from below for further information about Improving IVIVC’s.
IVIVC Test Systems for DDU and APSD
Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
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Inhaled Dissolution
In the case of inhaled and nasal drug delivery products, once the drug is deposited to the target site, the absorption or lung uptake, and hence the therapeutic effectiveness of the drug, depends on the active dissolving in the small amounts of aqueous fluid and lung surfactant available.
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Facemask Testing
One of the main factors influencing the amount of inhaled drug available to the patient is the interface between the facemask and the patient. Investigating and defining the effect of a facemask to the product’s DDU and APSD is important for the product development.
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Morphology
Whilst cascade impaction provides a useful indication of where inhaled drug particles are likely to deposit within the respiratory tract, it does not profile the morphological properties of these particles.
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Cold Freon® Effect
Cold Freon®” effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices.
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Related Inhaler Testing Products
For further information about the other products in our inhaler testing range, please select one of the options below.
Delivered Dose Uniformity (DDU)
Our range of Delivered Dose Uniformity (DDU) sampling apparatus are designed to help accurately assess the total amount of emitted drug.
Delivered Dose Uniformity (DDU)
View MoreAncillaries
Optimise inhaler testing workflows with our broad range of supporting equipment required to make up fully-operating test systems for Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) of orally inhaled and nasal drug products (OINDPs).
Ancillaries
View MoreSpecial Applications
Copley Scientific offers a range of testing equipment for additional qualification and validation of orally inhaled and nasal drug products (OINDPs), including assessments of generic drug formulations, inhaled dissolution testing and improving IVIVCs.
Special Applications
View MoreSemi-Automation
Take the labour out of inhaler testing with our semi-automated solutions.
Semi-Automation
View MoreAerodynamic Particle Size Distribution (APSD)
Our range of precision engineered cascade impactors measure the size distribution (particle size) of inhaled drug products, providing critical information about where particles in aerosol clouds are likely to be deposited in the lungs following inhalation.
Aerodynamic Particle Size Distribution (APSD)
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Related Services
Training
We offer a range of training courses, presentations and seminars covering a wide range of topics.
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Servicing
A comprehensive range of both in-house and on-site product servicing options are available
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Support
Our team of experienced technicians and engineers are on hand to help and advise
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