DDU of Nebulisers
The delivered dose testing of a nebulisers is carried out to determine the total amount of drug a patient might be expected to receive during a treatment period, rather than through one inhalation. Given the mode of operation of nebulisers, well-defined tidal breathing profiles for specific patient types are specified for testing. The two tests specified in the Pharmacopoeias to characterise delivered dose, Active Substance Delivery Rate and Total Active Substance Delivered, are based on tidal flow conditions generated by a breathing simulator, as opposed to fixed flow rates.
Breathing Simulator BRS 100i
View BrochureFilter Holder and Adapter
View BrochureMouthpiece Adapter
View BrochureAngle Adapter (for BRS 100i only)
View BrochureBRS 200i Breathing Simulator
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View BrochureAPSD of Nebulisers
View SystemBreathing Simulator BRS 100i
View BrochureFilter Holder and Adapter
View BrochureMouthpiece Adapter
View BrochureAngle Adapter (for BRS 100i only)
View BrochureBRS 200i Breathing Simulator
View BrochureLabel Printer
View BrochureAPSD of Nebulisers
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We also offer a range of equipment for additional MDI testing application support:
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Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
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One of the main factors influencing the amount of inhaled drug available to the patient is the interface between the facemask and the patient. Investigating and defining the effect of a facemask to the product’s DDU and APSD is important for the product development.
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Find Out MoreRelated News & Resources
Copley introduces the new Patient Exhalation Simulator to help with inhaler development to understand the impact of poor patient technique.
12th September 2023
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Copley introduces the new Flow Rate Sensor, a dedicated device for inhaler testing systems.
27th June 2023
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The new DUSA Shaker™ DTS 100i from Copley: For faster, safer, more repeatable inhaler testing
8th February 2023
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Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing
14th September 2022
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Copley Scientific joins the Industries Forum of the Taskforce for Lung Health
22nd June 2021
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Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio
1st March 2021
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Copley Scientific introduces improved test set-up for more representative inhaled product testing
5th August 2014
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More precise nebuliser testing as Copley Scientific launches NGI Cooler
29th April 2009
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Bridging the Gap: Enhancing the Clinical Realism of In Vitro OINDP Testing
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Understanding the Links Between Drug Delivery Route and In Vitro Test Methods
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Reducing Inhaler Testing Variability Through Test Environment Control
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Semi-Automating Inhaler Testing – A Good Idea, but Where to Start?
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Putting Inhalers to the Test
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A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing
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Optimizing the Role of Automation in Variability Reduction Strategies For Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) Testing of Inhaled Drug Products
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The Regulatory Landscape for OINDPs – The Biggest Shake-up in A Generation?
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Optimizing the Application of In Vitro Test Methods for the Demonstration of Bioequivalence in Orally Inhaled Products
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Demonstrating Bioequivalence of Orally Inhaled Products
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Optimising the Application of In Vitro Test Methods for the Demonstration of BE in OIPs
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