Special Applications

Copley Scientific offers a range of testing equipment for additional testing of orally inhaled and nasal drug products (OINDPs), including assessments of generic drug formulations, inhaled dissolution testing and improving IVIVCs.

Abbreviated Impactor Measurement (AIM)
Abbreviated Impactor Measurement (AIM)

If validated and implemented, abbreviated impactors could effectively speed up the process of screening formulations in the early development phases, prior to full resolution impactor studies being performed on the most promising candidates. In the QC environment, combined with Efficient Data Analysis (EDA), the reduced number of impactor stages required speeds up throughput and further reduces analytical error.

View More Details
USP Monographs (Generic Drug Development)
USP Monographs (Generic Drug Development)

USP monographs are most commonly used for product release testing, but may also be considered during product development.

View More Details
Cold Freon® Effect
Cold Freon® Effect

Cold Freon®” effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices.

View More Details
IVIVC
IVIVC

Better In Vitro – In Vivo Correlation (IVIVC) has long been an industry aim. This is particularly difficult in the case of inhaled and nasal products because of the complications involved in precisely correlating drug deposition behaviour with clinical efficacy, the impact of patient-to-patient variability and the complex interaction between formulation and device.
One strategy for improving the significance of cascade impaction data is to modify the test set-up in order to mimic the in vivo drug delivery process more closely.

View More Details
Inhaled Dissolution
Inhaled Dissolution

In the case of inhaled and nasal drug delivery products, once the drug is deposited to the target site, the absorption or lung uptake, and hence the therapeutic effectiveness of the drug, depends on the active dissolving in the small amounts of aqueous fluid and lung surfactant available.

View More Details
Facemask Testing
Facemask Testing

Many spacers/VHCs and nebulisers are used with facemasks instead of mouthpieces to administer the inhaled aerosol. This practice is commonplace in the case of infants and small children and in situations where the user lacks the capability of using a mouthpiece.

View More Details