Ancillaries

We offer a range of ancillary products required in addition to the dose collection device and cascade impactor to make up fully-operational systems for determining the Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) of orally inhaled and nasal drug products (OINDPs).

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Ancillaries for Inhaler Testing

Please select from the options below for further information.

Breathing Simulators

Used to apply a more clinically representative breathing profile (relative to a constant flow rate) during testing, our range of Breathing Simulators cover the variety of breathing patterns found in neonatal, infant, child and adult physiologies.

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Flow Controllers

Our Critical Flow Control TPK range and Breath Actuation Control BAC range are designed based on the requirements set out by both the European and the United States Pharmacopoeia for testing MDIs, DPIs, Nebulisers, ADIs and Nasal Products.

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Flow Meters

Both DDU and APSD data can be severely compromised if the inlet flow rate (the flow rate at the entrance to the induction port or DUSA) used during testing is inaccurate and/ or inconsistent, generating discrepancies with regard to its effects on both the cascade impactor itself and the inhaler under test.

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Vacuum Pumps

At the heart of every inhaler testing system is the Pump. We offer vacuum pumps specifically designed for use in the testing of MDIs, DPIs, nebulisers, nasal products and other types of OINDPs in accordance with the specifications laid down in the Ph. Eur. and USP.

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Environmental Control

Changes in laboratory temperature, relative humidity and even the presence of electrostatic charge have been identified as factors that can have a direct impact on the dose emission and aerosol generation performance of OINDPs, thereby compromising DDU and APSD test data integrity. We offer a range of environmental condition control solutions to help analysts improve the accuracy, sensitivity and reproducibility of inhaled product test data.

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NGI Cooler™

Eliminating evaporation induced by the thermal mass of the impactor, the NGI Cooler™ is designed to help maintain the integrity of the APSD of aerolised droplets by providing a temperature-controlled testing environment for devices such as nebulisers and ADIs.

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Inhaler Testing Workstation (ITW)

The hub of the OINDP testing system, the ITW is a modular workstation designed to keep test apparatus secure and organised during testing to help optimise busy workflows.

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Glass Expansion Chambers

Ideal for maximising the aerolisation of nasal drug products in the assessment of fine particles by cascade impaction, Glass Expansion Chambers are available for a wide range of nasal drug product applications.

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Mouthpiece & Nosepiece Adapters

Ensuring a proper seal is maintained between the device under test and the sampling apparatus, our range of Mouthpiece and Nosepiece Adapters are specially moulded from high quality silicone rubber to ensure superior performance. Adapters are available for the more common devices on the market, or can be custom-made for your specific device type.

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Related Inhaler Testing Products

For further information about the other products in our inhaler testing range, please select one of the options below.

Delivered Dose Uniformity (DDU)

Our range of Delivered Dose Uniformity (DDU) sampling apparatus are designed to help accurately assess the total amount of emitted drug.

Delivered Dose Uniformity (DDU)

Aerodynamic Particle Size Distribution (APSD)

Our range of precision engineered cascade impactors measure the size distribution (particle size) of inhaled drug products, providing critical information about where particles in aerosol clouds are likely to be deposited in the lungs following inhalation.

Aerodynamic Particle Size Distribution (APSD)

Special Applications

Copley Scientific offers a range of testing equipment for additional qualification and validation of orally inhaled and nasal drug products (OINDPs), including assessments of generic drug formulations, inhaled dissolution testing and improving IVIVCs.

Special Applications

Automation

Take the labour out of inhaler testing with our semi-automated solutions.

Automation

Improving IVIVCs

Better in vitro – in vivo correlation (IVIVC) has long been an industry aim. This is particularly difficult in the case of inhaled and nasal products because of the complications involved in precisely correlating drug deposition behaviour with clinical efficacy, the impact of patient-to-patient variability and the complex interaction between formulation and device. One strategy for improving the significance of cascade impaction data is to modify the test set-up in order to mimic the in vivo d

Improving IVIVCs

Inhalytix®

Inhalytix® – Our fully compliant data analysis software offers analysts a flexible and validated solution for the analysis and reporting of the aerodynamic particle size distribution (APSD) drug output from all OINDPs.