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Representative breathing patterns should be employed during inhaler testing that characterise the age and condition of the patients to be treated (paediatric to geriatric, mild to severe impairment of the lungs).
The use of Breathing Simulators to generate an inhalation and/or exhalation profile that mimics that of a human subject has become routine in OINDP testing, replacing existing constant flow conditions with breathing profiles more representative of conditions in vivo.
Exacerbated evaporation caused by the thermal mass of the NGI may be an issue for devices such as nebulisers that deliver the drug as an aerolised solution. Loss of solvent reduces droplet size, producing artificially low particle size measurements and compromises the integrity of APSD data.
The hub of an inhaler testing system, the ITW is a modular workstation designed to aid handling and manipulation of the various pieces of test apparatus and accessories, improving workflow. The ITW offers analysts the flexibility to pick and choose the attachments necessary for their test set-up needs. Simply connect the required attachments and start testing with greater ease.
The majority of nasal products are designed to generate droplets/particles with a mass median aerodynamic diameter (MMAD) of greater than 10 to 20 microns. This is to increase nasal deposition and minimise deposition in the lungs. However, most sprays deliver a proportion (typically <5%) of fine droplets in the <10 micron range. It is important to quantify this Fine Particle Dose (FPD) since it can penetrate beyond the nasal tract and into the lower respiratory tract or lungs, which may be undesirable. Cascade impactors are designed to capture particles in the range 0 to 10 microns and are widely used for this application.
Ensure a proper seal is maintained between the device under test and the sampling apparatus with our range of Mouthpiece and Nosepiece Adapters. Specially moulded from high quality silicone rubber to ensure superior performance, adapters are available for the more common devices on the market, or can be custom-made for your specific device type.
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