Tablet Dissolution Testing

All the DISi series are equipped with precision-ground shafts that will accept any of the baskets, paddles or rotating cylinders described in the Pharmacopoeias. Individual clutches enable each individual basket/paddle to be raised/lowered or engaged independently of the drive head making the series suitable for staggered starts, whilst also ensuring maximum user accessibility.

Compliant with USP/Eur. Ph. specifications, all DISi Series vessels feature unique Easy-Centre systems ensuring perfect positioning every time. UV-resistant vessels are also available. Easy-clean Viton® membrane-sealed low evaporation lids are included as standard with each vessel.

With dimensional tolerances a factor of 2 higher than those specified in the FDA Enhanced Calibration, the EMC Ultra Precision Dissolution Vessel brings even higher levels of accuracy to dissolution testing.

Eliminate the need for time-lag correction factor calculations with the Automatic Tablet Drop system. Guaranteeing simultaneous tablet ejection at the start of the test run, synchronised sampling is simplified.

We offer a range of dissolution sampling probe systems, designed for different user requirements, including manual sample processes, as well as automated sampling.

Formulated to produce reproducible results under standard dissolution test conditions, these standard drug references supplied by USP (Rockville, Maryland, USA) can be used to help verify the source of anomalies.

Streamlines laboratory data printing.

Copley offers equipment for three different methods for the determination of the rate of drug release from transdermal patches:

• Paddle Over Disk
• Watch Glass / Patch
• Rotating Cylinder

Based on the same principles as the Rotating Disk apparatus as described in USP Chapter <1087>, Copley offers punch and die kits, together with a hand operated press for intrinsic dissolution methods.

For dosage forms with small quantities, or extended release where much lower concentrations are required than that provided by the standard 1000 mL vessel, 100 mL and 200 mL conversion kits are available.

For solid dosage forms that have a tendency to block the standard 40 mesh basket, a basket with a coarser mesh is available to retain the dosage form in the basket, whilst allowing media penetration without clogging.

With the same basic basket specification as the USP standard, the special suppository basket provides the equivalent porosity to a basket of 10 mesh, allowing suppository dissolution testing to take place unimpeded.

In the case of inhaled and nasal drug delivery products, once the drug is deposited to the target site, the absorption or lung uptake, and hence the therapeutic effectiveness of the drug, depends on the active dissolving in the small amounts of aqueous fluid and lung surfactant available.