Breathing Simulators

From the generation of simple sinusoidal patterns as stated by the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of versatile Breathing Simulators can be used for a variety of testing applications and patient physiologies.

Breathing Simulator BRS 100i

BRS 100i Breathing Simulator

The BRS 100i is designed specifically for generating neonatal, infant, child and adult breathing patterns required for dose uniformity testing of nebulisers in accordance with ISO 27427:2013. It can also be used to generate the profiles required in USP <1602> for testing ‘Spacers and Valve Holding Chambers used with Inhalation Aerosols’.

  • Ph. Eur. 2.9.44, USP <1601> and USP <1602> compliant

  • Intuitive, touchscreen user interface

  • Extensive data output options

BRS 100i Technical Specifications
Volume (manually adjust):
0 to 800 mL
12 - 40 bpm
I:E Ratio:
1:1, 1:2 or 1:3
Patient Profile Suitability:
Neonate/Infant, Child, Adult
Inhalation and Exhalation
Select start on inhalation or exhalation stroke
User Interface:
Testing Nebulisers (Ph. Eur. 2.9.44 and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)
BRS 100i, Mixing Inlet, NGI

The BRS 100i can also be used in place of a standard vacuum pump with a cascade impactor such as the NGI or ACI and a Mixing Inlet to form a simple and inexpensive system for APSD studies utilising more representative patient profiles for MDIs with and without a spacer/VHC.

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