Understanding the dissolution behaviour of inhaled drug particles is critical for the performance and efficacy of Orally Inhaled Products (OIPs). Despite its importance, in vitro dissolution testing for inhaled formulations has historically received limited attention, and no standardised or compendial methods currently exist. The Inhaled Dissolution Apparatus (IDA) has been developed to fill this gap, offering a robust tool for evaluating inhaled drug dissolution.
Objective: This poster presents the evaluation of the IDA for quantifying dissolution performance of two Fluticasone Propionate (FP) inhalation products. The study focuses on key parameters including:
- Sensitivity to formulation differences
- Repeatability and reliability of results
- Impact of dose quantity on dissolution profiles
This research highlights the potential of the IDA to support in vitro testing of OIPs, providing valuable data for formulation development, quality control, and regulatory submission.
This poster was presented at DDL 2025.
