Cascade Impactor Metrics Guide

In this article you will learn about the key metrics used to analyse aerodynamic particle size distribution (APSD) data from cascade impaction testing of orally inhaled drug products. Copley Scientific Applications Specialist, Dr Clair Brooks, examines established measures including mass median aerodynamic diameter (MMAD), geometric standard deviation (GSD), fine particle dose (FPD) and fine particle fraction (FPF), alongside efficient data analysis approaches designed to reduce analytical burden. The article also explores the implications of USP <1604>, including current debate around the calculation and interpretation of cascade impactor data.

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