Whilst cascade impaction provides a useful indication of where inhaled drug particles are likely to deposit within the respiratory tract, it does not profile the morphological properties of these particles.
Generating component specific particle geometric size and shape data may be helpful in understanding differences between formulations and hence their potential bioavailability, even when APSDs are equivalent. This can be particularly useful in generic development when trying to replicate the performance of a reference product. The Malvern Glass Disc Cup, allows for collection of particles on a quartz glass disk, which can then be transferred to a Malvern Panalytical Morphologi 4-ID or equivalent system for morphological analysis.
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