• English
    • 简体中文 (Chinese (Simplified))
sales@copleyscientific.co.uk
+44 (0)115 961 6229
Enquire Today
  • Inhaler Testing
    • Delivered Dose Uniformity (DDU)
      • Metered-Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Ancillaries
      • Breathing Simulators
      • Flow Controllers
      • Flow Meters
      • Vacuum Pumps
      • Environmental Control
      • NGI Cooler™
      • Inhaler Testing Workstation™ (ITW)
      • Glass Expansion Chambers
      • Mouthpiece & Nosepiece Adapters
    • Special Applications
      • Abbreviated Impactor Measurement (AIM)
      • USP Monographs (Generic Drug Development)
      • Device Robustness / Inhaler Misuse
    • Aerodynamic Particle Size Distribution (APSD)
      • Metered Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Improving IVIVCs
      • IVIVC Test Systems for DDU and APSD
      • Inhaled Dissolution
      • Facemask Testing
      • Morphology
      • Cold Freon® Effect
    • Semi-Automation
      • Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols
      • Semi-Automation for DDU Testing
      • Semi-Automation for APSD Testing
    • APSD Data Analysis Software
      • Inhalytix®
  • Pharmaceutical Testing
    • Tablet Disintegration Testing
      • DTGi Series
    • Tablet Hardness Testing (Breaking Force)
      • Tablet Hardness Tester: TBF 100i
      • Tablet Hardness Tester: TH3
    • Suppository Testing
      • Suppository Disintegration Testing: SDT 1000
      • Vaginal Tablet Tester: VTT
    • Tablet Dissolution Testing
      • DISi Series
    • Powder Testing
      • Tapped Density: JVi Series
      • Bulk Density: Scott Volumeter
      • Flowability: BEP2
    • Tablet Thickness Testing
      • Tablet Thickness Tester 547
      • Tablet Thickness Tester 700
      • Digital Caliper Model 500
    • Tablet Friability Testing
      • Friabimat: Coated Tablets
      • FRVi Series: Uncoated Tablets
    • Semisolids Testing
      • Vertical Cell Diffusion Test System: HDT 1000
      • Vertical Diffusion Cell Test System: HDT 1
  • Detergent Testing
    • Tergotometer
      • Tergotometer: TRG 800i
  • Resources
    • Training
    • Servicing
    • Support
    • Downloads
  • News & Events
  • About Us
    • Our History
    • Faces of Copley
    • Careers
      • Current Vacancies
      • Our Culture & Values
      • Meet Our Team
      • Why Work for Copley?
      • Our History
      • Our Headquarters
  • Contact
    • Contact Us
    • Offices and Distributors
      • Find an Office or Distributor
      • Become a Distributor
  • Inhaler Testing
    • Delivered Dose Uniformity (DDU)
      • Metered-Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Ancillaries
      • Breathing Simulators
      • Flow Controllers
      • Flow Meters
      • Vacuum Pumps
      • Environmental Control
      • NGI Cooler™
      • Inhaler Testing Workstation™ (ITW)
      • Glass Expansion Chambers
      • Mouthpiece & Nosepiece Adapters
    • Special Applications
      • Abbreviated Impactor Measurement (AIM)
      • USP Monographs (Generic Drug Development)
      • Device Robustness / Inhaler Misuse
    • Aerodynamic Particle Size Distribution (APSD)
      • Metered Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Improving IVIVCs
      • IVIVC Test Systems for DDU and APSD
      • Inhaled Dissolution
      • Facemask Testing
      • Morphology
      • Cold Freon® Effect
    • Semi-Automation
      • Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols
      • Semi-Automation for DDU Testing
      • Semi-Automation for APSD Testing
    • APSD Data Analysis Software
      • Inhalytix®
  • Pharmaceutical Testing
    • Tablet Disintegration Testing
      • DTGi Series
    • Tablet Hardness Testing (Breaking Force)
      • Tablet Hardness Tester: TBF 100i
      • Tablet Hardness Tester: TH3
    • Suppository Testing
      • Suppository Disintegration Testing: SDT 1000
      • Vaginal Tablet Tester: VTT
    • Tablet Dissolution Testing
      • DISi Series
    • Powder Testing
      • Tapped Density: JVi Series
      • Bulk Density: Scott Volumeter
      • Flowability: BEP2
    • Tablet Thickness Testing
      • Tablet Thickness Tester 547
      • Tablet Thickness Tester 700
      • Digital Caliper Model 500
    • Tablet Friability Testing
      • Friabimat: Coated Tablets
      • FRVi Series: Uncoated Tablets
    • Semisolids Testing
      • Vertical Cell Diffusion Test System: HDT 1000
      • Vertical Diffusion Cell Test System: HDT 1
  • Detergent Testing
    • Tergotometer
      • Tergotometer: TRG 800i
  • Resources
    • Training
    • Servicing
    • Support
    • Downloads
  • News & Events
  • About Us
    • Our History
    • Faces of Copley
    • Careers
      • Current Vacancies
      • Our Culture & Values
      • Meet Our Team
      • Why Work for Copley?
      • Our History
      • Our Headquarters
  • Contact
    • Contact Us
    • Offices and Distributors
      • Find an Office or Distributor
      • Become a Distributor
Go back to News & Events

New download on Copley Scientific website considers particle size metrics for orally inhaled products

21 February 2012; Nottingham, UK: Copley Scientific has added a new, freely available download to its extensive library on the company website. ‘Calculating particle size distribution metrics for inhaled product characterization’ is a recently published paper authored by Mark Copley, Sales Director of Copley Scientific, and David Lewis from 3DI Solutions. It provides a review of the data processing techniques used to generate relevant aerodynamic particle size distribution (APSD) metrics for orally inhaled products (OIPs). A valuable reference for anyone working in the development and QC of this important class of pharmaceuticals, the paper can be downloaded Here.

Particle size is critical for OIPs because of its influence on the efficiency of drug delivery. The authors discuss this need for particle size data and how to efficiently derive key metrics from the substantial amount of data produced when using cascade impaction. Cascade impaction is the mandatory technique for measuring APSD measurement in all OIPs.

Cascade impaction involves size fractionation of a delivered dose. This enables the generation of an APSD specifically for the active pharmaceutical ingredient, rather than the entire formulation. Each sample is separated into around 7 or 8 fractions, each of which is analyzed by HPLC. Processing the resulting data to produce meaningful metrics is essential but can be complicated and potentially time-consuming.

Beginning with an introduction to cascade impaction ‘Calculating particle size distribution metrics for inhaled product characterization’ focuses on the calculation of mass median aerodynamic diameter (MMAD), comparing the different data regression techniques that can be applied in its determination. The simplicity, effectiveness and validity of direct linear interpolation is emphasised and, there is more general discussion of current efforts towards streamlined data analysis. Download this and other articles and white papers Here.

CAPTION: New paper on metrics begins with an introduction to cascade impaction

About Copley Scientific

Copley Scientific is recognised as the world’s leading manufacturer and supplier of inhaler test equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company is also active in detergent testing, air sampling and aerosol characterisation.

Copley Scientific’s pharmaceutical product range includes test equipment for: delivered dose uniformity and aerodynamic particle size measurement of metered-dose inhalers, dry powder inhalers, nebulizers and nasal sprays; as well as tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories and transdermals.

Copley Scientific has offices in the UK and Switzerland. The company works in partnership with aerosol particle science experts MSP Corporation in North America, and also distributes MSP Corporation’s air sampling and aerosol characterisation products throughout Europe.

Serving the pharmaceutical and associated industries, Copley Scientific offers an extensive range of equipment for research, development and quality control, as well as full validation and aftersales services. This broad range of products is supplied and supported worldwide through a network of specialist distributors. www.copleyscientific.com

Previous
Next
Contact Us Today

Have a question? Our friendly and experienced team are here to help.

T: +44 (0)115 961 6229 E: sales@copleyscientific.co.uk
Contact Us
Please review our privacy policy so you understand how we collect and use your personal data.
reCAPTCHA
Quality Logos
  • Contact
  • News & Events
  • Downloads
  • Privacy Policy
  • Anti-Bribery Policy
  • Terms and Conditions
  • Join Our Mailing List
Copley Scientific Limited, Colwick Quays Business Park, Road No. 2, Nottingham, NG4 2JY, United Kingdom
+44 (0)115 961 6229 +44 (0)115 961 7637 sales@copleyscientific.co.uk
© 2023 Copley Scientific Limited. Website by Fifteen
Copley wins East Midlands Chamber's Business of the Year Award 2022 for Nottinghamshire
Read the press release here
  • English
  • 简体中文 (Chinese (Simplified))