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    • Delivered Dose Uniformity (DDU)
      • Metered-Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Ancillaries
      • Breathing Simulators
      • Flow Controllers
      • Flow Meters
      • Vacuum Pumps
      • Environmental Control
      • NGI Cooler™
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      • Glass Expansion Chambers
      • Mouthpiece & Nosepiece Adapters
    • Special Applications
      • Abbreviated Impactor Measurement (AIM)
      • USP Monographs (Generic Drug Development)
    • Aerodynamic Particle Size Distribution (APSD)
      • Metered Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Improving IVIVCs
      • IVIVC Test Systems for DDU and APSD
      • Inhaled Dissolution
      • Facemask Testing
      • Morphology
      • Cold Freon® Effect
    • Semi-Automation
      • Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols
      • Semi-Automation for DDU Testing
      • Semi-Automation for APSD Testing
    • APSD Data Analysis Software
      • Inhalytix®
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      • Tablet Thickness Tester 547
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      • Digital Caliper Model 500
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      • Friabimat: Coated Tablets
      • FRVi Series: Uncoated Tablets
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Go back to News & Events

Introducing the new Alberta Idealized Throats from Copley Scientific – closer IVIVC in inhaled product testing

1 December 2010; Nottingham, UK: The Alberta Idealized Throat is a new product from Copley Scientific designed to improve in vivo/in vitro correlation (IVIVC) during inhaled product testing. Originally developed by the University of Alberta, Canada, and commercialized exclusively by Copley Scientific, the new throat is designed to provide a more ‘patient representative’ alternative to the USP/Ph Eur induction port, routinely used for aerodynamic particle size measurement by cascade impaction. Experimental work confirms the ability of the new throat to more precisely reflect deposition behaviour in the human throat, thereby improving the relevance of test data within an R & D environment.

Achieving acceptable correlation between in vitro test methods and in vivo behaviour is a major challenge for the inhaled product sector. Research has shown that the USP/Ph.Eur. induction port that currently is widely used with cascade impactors for all inhaled products, can underestimate deposition in the human throat. Although highly effective as a simple QC tool, this compromises the value of the data for efficient R & D.

The Alberta Idealized Throat was developed as a consequence of extensive research into typical patient populations, including the review of CT scans and anatomy texts. The Alberta Idealized Throat has standardised, highly reproducible, human-like geometry, offering robust performance that is independent of flow rate. The Alberta Highly Idealized Throat has a smooth, more uniform internal geometry than a human throat cast, making drug recovery much simpler. This is further aided by a two-piece construction, utilising quick- release clips for easy internal access.

For more details visit www.copleyscientific.com

CAPTION: The Alberta Idealized Throat from Copley Scientific

About Copley Scientific

Copley Scientific is recognised as the world’s leading manufacturer and supplier of inhaler test equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company is also active in detergent testing, air sampling and aerosol characterisation.

Copley Scientific’s pharmaceutical product range includes test equipment for: delivered dose uniformity and aerodynamic particle size measurement of metered-dose inhalers, dry powder inhalers, nebulizers and nasal sprays; as well as tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories and transdermals.

Copley Scientific has offices in the UK and Switzerland. The company works in partnership with aerosol particle science experts MSP Corporation in North America, and also distributes MSP Corporation’s air sampling and aerosol characterisation products throughout Europe.

Serving the pharmaceutical and associated industries, Copley Scientific offers an extensive range of equipment for research, development and quality control, as well as full validation and aftersales services. This broad range of products is supplied and supported worldwide through a network of specialist distributors. www.copleyscientific.com

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Copley wins East Midlands Chamber's Business of the Year Award 2022 for Nottinghamshire
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