• English
    • 简体中文 (Chinese (Simplified))
sales@copleyscientific.co.uk
+44 (0)115 961 6229
Enquire Today
  • Inhaler Testing
    • Delivered Dose Uniformity (DDU)
      • Metered-Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Ancillaries
      • Breathing Simulators
      • Flow Controllers
      • Flow Meters
      • Vacuum Pumps
      • Environmental Control
      • NGI Cooler™
      • Inhaler Testing Workstation™ (ITW)
      • Glass Expansion Chambers
      • Mouthpiece & Nosepiece Adapters
    • Special Applications
      • Abbreviated Impactor Measurement (AIM)
      • USP Monographs (Generic Drug Development)
    • Aerodynamic Particle Size Distribution (APSD)
      • Metered Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Improving IVIVCs
      • IVIVC Test Systems for DDU and APSD
      • Inhaled Dissolution
      • Facemask Testing
      • Morphology
      • Cold Freon® Effect
    • Semi-Automation
      • Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols
      • Semi-Automation for DDU Testing
      • Semi-Automation for APSD Testing
    • APSD Data Analysis Software
      • Inhalytix®
  • Pharmaceutical Testing
    • Tablet Disintegration Testing
      • DTGi Series
    • Tablet Hardness Testing (Breaking Force)
      • Tablet Hardness Tester: TBF 100i
      • Tablet Hardness Tester: TH3
    • Suppository Testing
      • Suppository Disintegration Testing: SDT 1000
      • Vaginal Tablet Tester: VTT
    • Tablet Dissolution Testing
      • DISi Series
    • Powder Testing
      •  Tapped Density: JVi Series
      • Bulk Density: Scott Volumeter
      • Flowability: BEP2
    • Tablet Thickness Testing
      • Tablet Thickness Tester 547
      • Tablet Thickness Tester 700
      • Digital Caliper Model 500
    • Tablet Friability Testing
      • Friabimat: Coated Tablets
      • FRVi Series: Uncoated Tablets
    • Semisolids Testing
      • Vertical Diffusion Cell Test System: HDT 1000
      • Vertical Diffusion Cell Test System: HDT 1
  • Detergent Testing
    • Tergotometer
      • Tergotometer: TRG 800i
  • Resources
    • Training
    • Servicing
    • Support
    • Downloads
  • News & Events
  • About Us
    • Our History
    • Faces of Copley
    • Careers
      • Current Vacancies
      • Our Culture & Values
      • Meet Our Team
      • Why Work for Copley?
      • Our History
      • Our Office
  • Contact
    • Contact Us
    • Offices and Distributors
      • Find an Office or Distributor
      • Become a Distributor
  • Inhaler Testing
    • Delivered Dose Uniformity (DDU)
      • Metered-Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Ancillaries
      • Breathing Simulators
      • Flow Controllers
      • Flow Meters
      • Vacuum Pumps
      • Environmental Control
      • NGI Cooler™
      • Inhaler Testing Workstation™ (ITW)
      • Glass Expansion Chambers
      • Mouthpiece & Nosepiece Adapters
    • Special Applications
      • Abbreviated Impactor Measurement (AIM)
      • USP Monographs (Generic Drug Development)
    • Aerodynamic Particle Size Distribution (APSD)
      • Metered Dose Inhalers (MDIs)
      • Dry Powder Inhalers (DPIs)
      • Nebulisers
      • Aqueous Droplet Inhalers (ADIs)
      • Nasal Products
    • Improving IVIVCs
      • IVIVC Test Systems for DDU and APSD
      • Inhaled Dissolution
      • Facemask Testing
      • Morphology
      • Cold Freon® Effect
    • Semi-Automation
      • Automated Shake, Fire and Flow Control for MDIs, Nasal Sprays and Aerosols
      • Semi-Automation for DDU Testing
      • Semi-Automation for APSD Testing
    • APSD Data Analysis Software
      • Inhalytix®
  • Pharmaceutical Testing
    • Tablet Disintegration Testing
      • DTGi Series
    • Tablet Hardness Testing (Breaking Force)
      • Tablet Hardness Tester: TBF 100i
      • Tablet Hardness Tester: TH3
    • Suppository Testing
      • Suppository Disintegration Testing: SDT 1000
      • Vaginal Tablet Tester: VTT
    • Tablet Dissolution Testing
      • DISi Series
    • Powder Testing
      •  Tapped Density: JVi Series
      • Bulk Density: Scott Volumeter
      • Flowability: BEP2
    • Tablet Thickness Testing
      • Tablet Thickness Tester 547
      • Tablet Thickness Tester 700
      • Digital Caliper Model 500
    • Tablet Friability Testing
      • Friabimat: Coated Tablets
      • FRVi Series: Uncoated Tablets
    • Semisolids Testing
      • Vertical Diffusion Cell Test System: HDT 1000
      • Vertical Diffusion Cell Test System: HDT 1
  • Detergent Testing
    • Tergotometer
      • Tergotometer: TRG 800i
  • Resources
    • Training
    • Servicing
    • Support
    • Downloads
  • News & Events
  • About Us
    • Our History
    • Faces of Copley
    • Careers
      • Current Vacancies
      • Our Culture & Values
      • Meet Our Team
      • Why Work for Copley?
      • Our History
      • Our Office
  • Contact
    • Contact Us
    • Offices and Distributors
      • Find an Office or Distributor
      • Become a Distributor
Go back to News & Events

Measuring the ‘cold freon’ effect – Copley Scientific’s new PTT 1000 takes the temperature of inhaled aerosols

27 September 2012; Nottingham, UK: Copley Scientific has launched the Plume Temperature Tester PTT 1000, a high precision instrument for measuring the plume temperature of Metered-Dose Inhalers (MDIs) and nasal sprays. The PTT 1000 is the first instrument on the market that can reliably measure plume temperature during dose delivery, to support determination of the ‘cold freon’ effect – the chilling sensation that inhaler users often experience. Since this effect can directly impact the consistency and efficiency of drug delivery, the new tester is particularly useful for those seeking to demonstrate therapeutic equivalence or to develop softer, warmer plumes with improved patient compliance rates.

The widely recognised ‘cold freon’ effect is due to the high velocity blast and subsequent evaporation of liquid propellant that impact the back of the user’s throat during drug delivery. Since the effect is a function of both aerosol spray force and plume temperature, Copley Scientific offers the PTT 1000 alongside the Spray Force Tester 1000, an instrument that measures the impaction force of delivery. Together these provide a combined solution for complete quantification.

In certain instances the ‘cold freon’ effect can result in the patient aborting the inhalation process and is therefore a significant cause of inconsistent drug delivery. As a result, this effect is specifically given as an example of a criteria that might be required to substantiate in vitro therapeutic equivalence in EMA guidelines for orally inhaled products (OIP) (January 2009).

With an internal geometry identical to that of the standard USP induction port used for all orally inhaled product testing, the PTT 1000 incorporates a series of four thermocouples that measure a precise temperature profile of the plume at different distances from the actuator. A data acquisition system under the control of an associated PC ensures efficient data capture and display, and the thermocouples are easily removed for cleaning. The new tester can be directly connected to a Waste Shot collector or Dose Uniformity Sampling Apparatus for streamlined integration within existing test set-ups.

For further information on the new the Copley Plume Temperature Tester PTT 1000 please go to: http://bit.ly/COPCSC

CAPTION: Plume Temperature Tester PTT 1000

About Copley Scientific

Copley Scientific is recognised as the world’s leading manufacturer and supplier of inhaler test equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company is also active in detergent testing, air sampling and aerosol characterisation.

Copley Scientific’s pharmaceutical product range includes test equipment for: delivered dose uniformity and aerodynamic particle size measurement of metered-dose inhalers, dry powder inhalers, nebulizers and nasal sprays; as well as tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories and transdermals.

Copley Scientific has offices in the UK and Switzerland. The company works in partnership with aerosol particle science experts MSP Corporation in North America, and also distributes MSP Corporation’s air sampling and aerosol characterisation products throughout Europe.

Serving the pharmaceutical and associated industries, Copley Scientific offers an extensive range of equipment for research, development and quality control, as well as full validation and aftersales services. This broad range of products is supplied and supported worldwide through a network of specialist distributors. www.copleyscientific.com

Previous
Next
Contact Us Today

Have a question? Our friendly and experienced team are here to help.

T: +44 (0)115 961 6229 E: sales@copleyscientific.co.uk
Contact Us
Please review our privacy policy so you understand how we collect and use your personal data.
reCAPTCHA
Quality Logos
  • Contact
  • News & Events
  • Downloads
  • Privacy Policy
  • Anti-Bribery Policy
  • Terms and Conditions
  • Join Our Mailing List
Copley Scientific Limited, Colwick Quays Business Park, Road No. 2, Nottingham, NG4 2JY, United Kingdom
+44 (0)115 961 6229 +44 (0)115 961 7637 sales@copleyscientific.co.uk
© 2023 Copley Scientific Limited. Website by Fifteen
  • English
  • 简体中文 (Chinese (Simplified))