New equipment from Copley Scientific makes it easy and straightforward to test the performance of semisolid pharmaceuticals used principally for dermatological therapies, in accordance with the latest United States Pharmacopoeia (USP) specifications. The Vertical Diffusion Cell Test System Model HDT 1000 comprises a compact unit with 10 test stations that enables the precise control of test conditions required, combined with two new Vertical Diffusion Cells that allow for simple, reproducible analysis. Used together these enable efficient and accurate testing in accordance with the specifications in USP chapter <1724>.
USP chapter <1724>, admitted in the first supplement to USP 37, introduced compendial methods specifically for the performance testing semisolids for the first time. These are defined as creams, ointments, gels or lotions for topical application, designed to deliver a localised therapeutic effect. The unit can also be used for permeation studies on transdermal patches as per the EMA “Guideline on quality of transdermal patches” effective 17th June 2015.
With a compact, two-cell width, front to back layout, the HDT 1000 allows easy access to every cell in the test station, while at the same time minimising the bench space required for test equipment. Utilising a precision heating block, it allows the precise control of temperature and agitation speed via a magnetic stirrer bar in each individual cell, thus eradicating the “spaghetti” of tubing and bulky water bath typically used on other cell-based systems.
Two sizes of Vertical Diffusion Cell are available corresponding to the Models “B” (11.28 mm diameter, 7 mL capacity) and “C” (15 mm diameter, 11 mL capacity) described in the USP. Both cells feature a unique clamping system to replace the conventional clamps used on traditional cells to simplify cell preparation and are also fitted with a side sampling arm to facilitate bubble-free filling, sample withdrawal and media replacement.
All cells are supplied complete with individual cell tops for both “open” and “closed or occluded” operation. Various synthetic membranes for use with the cells are available on request.
To find out more about the new semisolids testing equipment please contact Copley Scientific firstname.lastname@example.org
About Copley Scientific
Copley Scientific is recognised as the world’s leading manufacturer and supplier of inhaler test equipment and is a major provider of testing systems for other pharmaceutical dosage forms. The company is also active in detergent testing, air sampling and aerosol characterisation.
Copley Scientific’s pharmaceutical product range includes test equipment for delivered dose uniformity and aerodynamic particle size measurement of metered-dose inhalers, dry powder inhalers, nebulizers and nasal sprays; as well as tablets (dissolution, disintegration, friability and hardness) capsules, powders, suppositories and transdermals.
Copley Scientific has offices in the UK and Switzerland. The company works in partnership with aerosol particle science experts MSP Corporation in North America and also distributes MSP Corporation’s air sampling and aerosol characterisation products throughout Europe.
Serving the pharmaceutical and associated industries, Copley Scientific offers an extensive range of equipment for research, development and quality control, as well as full validation and aftersales services. This broad range of products is supplied and supported worldwide through a network of specialist distributors.