Cascade Impactors – Theory, Design and Practical Information for Optimal Testing
Since aerodynamic particle size correlates directly with regional deposition in the lungs and respiratory tract, effective delivery of API relies on achieving inhalation of drug in a particular particle size range known as the fine particle fraction (FPF). Particles
larger than 4-6 m will deposit in the trachea or upper respiratory tract instead of in the lungs; particles below 1 m may be exhaled. As a result, accurate characterization of particles for pharmaceutical aerosols is crucial, and the measurement range is
generally less than 10 m.
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