ONdrugDelivery Article 2011

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Refining Inhaled Product Testing

Reliable and relevant analytical data provide a robust foundation for the efficient development and manufacture of efficacious products. For pharmaceuticals, secure relationships between in vitro test data and in vivo behaviour (in vitro-in vivo relationships – IVIVRs) are especially useful, but they remain a challenge in the area of inhaled drug delivery. Here, Mark Copley, Sales Director at Copley Scientific, considers how inhaled product testing is being refined towards the goal of better in vivo representation, and greater overall productivity. The focus of the article is cascade impaction, the technique used for aerodynamic particle size distribution measurement for all orally inhaled and nasal drug products (OINDPs).