Breathing Simulators

From the generation of simple sinusoidal patterns as stated in the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of Breathing Simulators can be used across a variety of testing applications and patient physiologies.

BRS 200i Breathing Simulator

The BRS 200i is a breathing simulator with up to 900 mL volume suitable for the testing of Nebulisers and MDIs with Spacers and Valve Holding Chambers (VHCs). Specifically designed to generate all of the breathing profiles used to measure the drug delivery rate and tidal drug delivered of nebulisers according to Ph. Eur. 2.9.44 and USP <1601> and MDIs used with a spacer/VHC as per USP <1602>, the BRS 200i is also suitable for generating other wave forms in studies to improve IVIVCs.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Improved accuracy for infant and neonate profile volume requirements

  • Extensive data output options

BRS 200i Features
0 to 900 mL
6 – 60 bpm
I:E ratio:
Sinusoidal, Square, Triangular, User-defined (flow vs time)
Inhalation and/or Exhalation
On inhalation or exhalation stroke / User-defined profiles (flow vs time)
User interface:
Testing Nebulisers (Ph. Eur. 2.9.44) and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

BRS 200i User Interface

  • BRS 200i user log-in screen


  • Pre-defined breathing pattern method selection
  • Customisation and creation of breathing pattern methods
  • Main run test screen (ready to test)

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