Breathing Simulators

From the generation of simple sinusoidal patterns as stated in the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of Breathing Simulators can be used across a variety of testing applications and patient physiologies.

BRS 200i Breathing Simulator

The BRS 200i is a breathing simulator with up to 900 mL volume suitable for the testing of Nebulisers and MDIs with Spacers and Valve Holding Chambers (VHCs). Specifically designed to generate all of the breathing profiles used to measure the drug delivery rate and tidal drug delivered of nebulisers according to Ph. Eur. 2.9.44 and USP <1601> and MDIs used with a spacer/VHC as per USP <1602>, the BRS 200i is also suitable for generating other wave forms in studies to improve IVIVCs.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Improved accuracy for infant and neonate profile volume requirements

  • Extensive data output options

BRS 200i Features
Volume:
0 to 900 mL
Frequency:
6 – 60 bpm
I:E ratio:
Variable
Waveforms:
Sinusoidal, Square, Triangular, User-defined (flow vs time)
Profile:
Inhalation and/or Exhalation
Start:
On inhalation or exhalation stroke / User-defined profiles (flow vs time)
User interface:
Touchscreen
Uses:
Testing Nebulisers (Ph. Eur. 2.9.44) and USP <1601> Testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs with Spacers/VHCs and nebulisers: With Filter Holder and Adapter (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

BRS 200i User Interface

  • BRS 200i user log-in screen

 

  • Pre-defined breathing pattern method selection
  • Customisation and creation of breathing pattern methods
  • Main run test screen (ready to test)

Related Accessories

Related Services

Related News & Resources

Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

22nd June 2021

Find out more

Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio

1st March 2021

Find out more

Copley Scientific introduces new, upgraded breath simulators for inhaled product testing

13th November 2017

Find out more

Copley Scientific publishes new white paper: ‘Using breathing simulators to enhance inhaled product testing’

10th April 2014

Find out more

Putting Inhalers to the Test

View download

A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing

View download

ONdrugDelivery Article: December 2018Variability in Cascade Impaction: Sources, Impact and Strategies for Reduction

View download

Optimizing the Application of In Vitro Test Methods for the Demonstration of Bioequivalence in Orally Inhaled Products

View download

Demonstrating Bioequivalence of Orally Inhaled Products

View download

Optimising the Application of In Vitro Test Methods for the Demonstration of BE in OIPs

View download