Breathing Simulators

From the generation of simple sinusoidal patterns as stated in the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of Breathing Simulators can be used across a variety of testing applications and patient physiologies.

BRS 300i Breathing Simulator

Similar in design and operation to the BRS 200i, the BRS 300i has a larger volume of 0 mL – 5 L. It also features a maximum flow rate of 240 L/min (free flow) and a maximum acceleration of 25L/s2 (free flow) making it the ideal unit for the testing of MDIs and DPIs for improved IVIVCs.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Powerful drive system for generating challenging profiles

  • Extensive data output options

BRS 300i Technical Specifications
0 mL to 5 L
6 – 60 bpm
I:E ratio:
Sinusoidal, Square, Triangular, User-defined (flow vs time)
Inhalation and/or Exhalation
On inhalation or exhalation stroke / User-defined profiles (flow vs time)
User interface:
Limited testing of Nebulisers (Ph. Eur. 2.9.44 and USP <1601> and testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs and DPIs: With DUSA for MDI/DPI (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

BRS 300i User Interface

  • BRS 300i user log-in screen
  • Pre-defined breathing pattern method selection
  • Customisation and creation of breathing pattern methods
  • Main run test screen (ready to test)

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