Breathing Simulators

Representative breathing patterns should be employed during inhaler testing that characterise the age and condition of the patients to be treated (paediatric to geriatric, mild to severe impairment of the lungs).
The Copley range of Breathing Simulators are designed to generate an inhalation and/or exhalation profile that mimics that of a human subject and have become routinely used in orally inhaled product testing to replace existing constant flow conditions with breathing profiles more representative of conditions in vivo.

Breathing Simulator BRS 300i

BRS 300i - Breathing Simulator

Similar in design and operation to the BRS 200i, the BRS 300i has a larger volume of 0 mL - 5 L. It also features a maximum flow rate of 240 L/min (free flow) and a maximum acceleration of 25L/s2 making it the ideal unit for the testing of MDIs and DPIs for improved IVIVCs.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Powerful drive system for generating challenging profiles

  • Extensive data output options

BRS 300i Features
0 mL to 5 L
6 - 60 bpm
I:E Ratio:
Sinusoidal, Square, Triangular, User defined (flow vs time)
Inhalation and/or Exhalation
On inhalation or exhalation stroke User defined profiles (flow vs time)
User Interface:
Limited testing of Nebulisers (Ph. Eur. 2.9.44 and USP <1601> and testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs and DPIs: With DUSA for MDI/DPI (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

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