Breathing Simulators

From the generation of simple sinusoidal patterns as stated by the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of versatile Breathing Simulators can be used for a variety of testing applications and patient physiologies.

Breathing Simulator BRS 300i

BRS 300i Breathing Simulator

Similar in design and operation to the BRS 200i, the BRS 300i has a larger volume of 0 mL - 5 L. It also features a maximum flow rate of 240 L/min (free flow) and a maximum acceleration of 25L/s2 (free flow) making it the ideal unit for the testing of MDIs and DPIs for improved IVIVCs.

  • 21 CFR Part 11 compliant

  • Stores and recalls methods

  • Powerful drive system for generating challenging profiles

  • Extensive data output options

BRS 300i Technical Specifications
0 mL to 5 L
6 - 60 bpm
I:E ratio:
Sinusoidal, Square, Triangular, User-defined (flow vs time)
Inhalation and/or Exhalation
On inhalation or exhalation stroke / User-defined profiles (flow vs time)
User interface:
Limited testing of Nebulisers (Ph. Eur. 2.9.44 and USP <1601> and testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs and DPIs: With DUSA for MDI/DPI (Dose Uniformity) With Impactor and Mixing Inlet (APSD)

BRS 300i User Interface

  • BRS 300i user log-in screen
  • Pre-defined breathing pattern method selection
  • Customisation and creation of breathing pattern methods
  • Main run test screen (ready to test)

Related Accessories

Real-Time Breath Verification Chamber

Enables measurement and recording of the breathing profile generated through the inhaler during the actual test itself, using the Flow Certifier available in the Qualification Kit. Support Arm (Cat. No. 9113) required. For use with the USP Induction Port only.
View Brochure

Real-Time Breath Verification Chamber

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