The Cold Freon® effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices. Caused by impaction of the delivered dose and the rapid evaporation of any remaining propellant, the “cold Freon®” effect strongly influences the efficiency of drug delivery. It may, for example, cause the patient to abort or be unsuccessful in completing the inhalation manoeuvre.
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