DDU of Metered-Dose Inhalers (MDIs)

MDI Metered Dose Inhaler Aerosol characteristics are relatively insensitive to changes in air flow rate because the Aerosolisation and dispersion mechanisms are dependent on the force generated by the propellant, rather than the patient’s inspiratory effort. Therefore, for MDI testing the flow rate is fixed at an arbitrary value of 28.3 L/min. A vacuum pump is used to draw air through the assembled test set-up at this flow rate. However, these test conditions are not applied for DDU Testing when the Metered Dose Inhaler is intended for use with an add-on device such as a spacer or valved holding chamber (VHC).

DDU of Dry Powder Inhalers (DPIs)

Breath-Actuated MDIs (BAIs)

The Breath Actuation Controller BAC 100i can also be used for the testing of Breath-Actuated (or Breath-Operated) MDIs. In this case, the BAC 100i is used to initiate the flow, simultaneously triggering the breath-actuated inhaler.

Vertus III with DUSA Stack and Priming& Waste Module

MDIs: Automated DDU Testing

The Vertus® III automated shake, fire and shot waste range is made up of integrated turn-key solutions for precise, controlled and reproducible MDI metered dose inhaler testing. Compatible with most MDIs, the Vertus III MDI testing systems offer analysts complete control over:

  • The speed, angle and duration of shaking, ahead of actuation
  • Firing force and the speed of application and release of that force
  • The time delay between the end of shaking and device actuation
Find out more

Related Applications

We also offer a range of equipment for additional MDI testing application support:

Automation Tools

Improve efficiency
Reduce variability
Eliminate handling errors
Increase testing capacity

Related Services

Related News & Resources

New, automated shake and fire platforms from Copley cut the burden of MDI and nasal drug product testing.

7th November 2023

Find out more

The new DUSA Shaker™ DTS 100i from Copley: For faster, safer, more repeatable inhaler testing

8th February 2023

Find out more

Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing

14th September 2022

Find out more

Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

22nd June 2021

Find out more

Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio

1st March 2021

Find out more

New e-Training service from Copley for pharmaceutical testing

29th January 2021

Find out more

Advancing the science of OINDPs: Copley Scientific joins IPAC-RS

28th February 2018

Find out more

Copley Scientific launches new products for MDI testing in line with the new USP monograph

23rd January 2014

Find out more

Perfect Timing for the Automation of OINDP Testing

View download

Understanding the Links Between Drug Delivery Route and In Vitro Test Methods

View download

Investigating the Impact of Electrostatics on Delivered Dose Uniformity for pMDIs

View download

Reducing Inhaler Testing Variability Through Test Environment Control

View download

The Combined Effect of Valve and Spray Orifice Diameters on pMDI Plume Force

View download

Semi-Automating Inhaler Testing – A Good Idea, but Where to Start?

View download

Putting Inhalers to the Test

View download

A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing

View download

Optimizing the Role of Automation in Variability Reduction Strategies For Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) Testing of Inhaled Drug Products

View download

The Regulatory Landscape for OINDPs – The Biggest Shake-up in A Generation?

View download

Optimizing the Application of In Vitro Test Methods for the Demonstration of Bioequivalence in Orally Inhaled Products

View download

Optimising the Application of In Vitro Test Methods for the Demonstration of BE in OIPs

View download

Characterizing the Performance of Metered Dose Inhalers with Add-On Devices: New Methods For Clinically Relevant Testing

View download

A New, Advanced High-Throughput System for Automated Inhaler Testing

View download