DDU of Metered-Dose Inhalers (MDIs)
MDI Metered Dose Inhaler Aerosol characteristics are relatively insensitive to changes in air flow rate because the Aerosolisation and dispersion mechanisms are dependent on the force generated by the propellant, rather than the patient’s inspiratory effort. Therefore, for MDI testing the flow rate is fixed at an arbitrary value of 28.3 L/min. A vacuum pump is used to draw air through the assembled test set-up at this flow rate. However, these test conditions are not applied for DDU Testing when the Metered Dose Inhaler is intended for use with an add-on device such as a spacer or valved holding chamber (VHC).
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Breath-Actuated MDIs (BAIs)
The Breath Actuation Controller BAC 100i can also be used for the testing of Breath-Actuated (or Breath-Operated) MDIs. In this case, the BAC 100i is used to initiate the flow, simultaneously triggering the breath-actuated inhaler.
MDIs: Automated DDU Testing
The Vertus® III automated shake, fire and shot waste range is made up of integrated turn-key solutions for precise, controlled and reproducible MDI metered dose inhaler testing. Compatible with most MDIs, the Vertus III MDI testing systems offer analysts complete control over:
- The speed, angle and duration of shaking, ahead of actuation
- Firing force and the speed of application and release of that force
- The time delay between the end of shaking and device actuation
Related Applications
We also offer a range of equipment for additional MDI testing application support:
Related Applications
Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
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Automation Tools
Improve efficiency
Reduce variability
Eliminate handling errors
Increase testing capacity Automation Tools
All of the tests involved in Delivered Dose Uniformity require the collection and drug recovery of individual doses into the collection tube of a Dosage Unit Sampling Apparatus (DUSA) appropriate to its type (MDI or DPI) prior to assay.
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Automation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
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Automation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
View Product Range
Automation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
View Product Range
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Training
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A comprehensive range of both in-house and on-site product servicing options are available
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