DDU of Metered-Dose Inhalers (MDIs)
MDI Metered Dose Inhaler Aerosol characteristics are relatively insensitive to changes in air flow rate because the Aerosolisation and dispersion mechanisms are dependent on the force generated by the propellant, rather than the patient’s inspiratory effort. Therefore, for MDI testing the flow rate is fixed at an arbitrary value of 28.3 L/min. A vacuum pump is used to draw air through the assembled test set-up at this flow rate. However, these test conditions are not applied for DDU Testing when the Metered Dose Inhaler is intended for use with an add-on device such as a spacer or valved holding chamber (VHC).
Low Capacity Pump LCP6
View BrochureBreath Actuation Controller BAC 100i
View BrochureInhaler Testing Workstation ITW
View BrochureDose Uniformity Sampling Apparatus (DUSA) for MDIs
View BrochureFlow Rate Sensor FRS
View BrochureWaste Shot Collector WSC2
View BrochureMouthpiece Adapter
View BrochureEnviroMate™ – Benchtop Environmental Chamber
View BrochureDUSA Stand for MDIs
View BrochureFlow Meter DFM 2000
View BrochureMDI Actuation Sensor
View BrochureTemperature/Humidity Sensor
View BrochureLabel Printer
View BrochureAPSD of Metered Dose Inhalers (MDIs)
View SystemLow Capacity Pump LCP6
View BrochureBreath Actuation Controller BAC 100i
View BrochureInhaler Testing Workstation ITW
View BrochureDose Uniformity Sampling Apparatus (DUSA) for MDIs
View BrochureFlow Rate Sensor FRS
View BrochureWaste Shot Collector WSC2
View BrochureMouthpiece Adapter
View BrochureEnviroMate™ – Benchtop Environmental Chamber
View BrochureDUSA Stand for MDIs
View BrochureFlow Meter DFM 2000
View BrochureMDI Actuation Sensor
View BrochureTemperature/Humidity Sensor
View BrochureLabel Printer
View BrochureAPSD of Metered Dose Inhalers (MDIs)
View SystemBreath-Actuated MDIs (BAIs)
The Breath Actuation Controller BAC 100i can also be used for the testing of Breath-Actuated (or Breath-Operated) MDIs. In this case, the BAC 100i is used to initiate the flow, simultaneously triggering the breath-actuated inhaler.
MDIs: Automated DDU Testing
The Vertus® III automated shake, fire and shot waste range is made up of integrated turn-key solutions for precise, controlled and reproducible MDI metered dose inhaler testing. Compatible with most MDIs, the Vertus III MDI testing systems offer analysts complete control over:
- The speed, angle and duration of shaking, ahead of actuation
- Firing force and the speed of application and release of that force
- The time delay between the end of shaking and device actuation
Related Applications
We also offer a range of equipment for additional MDI testing application support:
Related Applications
Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
View MoreAutomation Tools
Automation Tools
All of the tests involved in Delivered Dose Uniformity require the collection and drug recovery of individual doses into the collection tube of a Dosage Unit Sampling Apparatus (DUSA) appropriate to its type (MDI or DPI) prior to assay.
View Product RangeAutomation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
View Product RangeAutomation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
View Product RangeAutomation Tools
Copley offers a range of ready-made flexible shake, fire and flow control systems for individual MDI testing with ACI, NGI, DUSA, waste shot collectors and other devices.
View Product RangeRelated Services
Training
We offer a range of training courses, presentations and seminars covering a wide range of topics.
Find Out MoreServicing
A comprehensive range of both in-house and on-site product servicing options are available
Find Out MoreSupport
Our team of experienced technicians and engineers are on hand to help and advise
Find Out MoreRelated News & Resources
New, automated shake and fire platforms from Copley cut the burden of MDI and nasal drug product testing.
7th November 2023
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The new DUSA Shaker™ DTS 100i from Copley: For faster, safer, more repeatable inhaler testing
8th February 2023
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Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing
14th September 2022
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Copley Scientific joins the Industries Forum of the Taskforce for Lung Health
22nd June 2021
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Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio
1st March 2021
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Copley Scientific launches new products for MDI testing in line with the new USP monograph
23rd January 2014
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Perfect Timing for the Automation of OINDP Testing
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Understanding the Links Between Drug Delivery Route and In Vitro Test Methods
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Investigating the Impact of Electrostatics on Delivered Dose Uniformity for pMDIs
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Reducing Inhaler Testing Variability Through Test Environment Control
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The Combined Effect of Valve and Spray Orifice Diameters on pMDI Plume Force
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Semi-Automating Inhaler Testing – A Good Idea, but Where to Start?
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Putting Inhalers to the Test
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A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing
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Optimizing the Role of Automation in Variability Reduction Strategies For Delivered Dose Uniformity (DDU) and Aerodynamic Particle Size Distribution (APSD) Testing of Inhaled Drug Products
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The Regulatory Landscape for OINDPs – The Biggest Shake-up in A Generation?
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Optimizing the Application of In Vitro Test Methods for the Demonstration of Bioequivalence in Orally Inhaled Products
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Optimising the Application of In Vitro Test Methods for the Demonstration of BE in OIPs
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Characterizing the Performance of Metered Dose Inhalers with Add-On Devices: New Methods For Clinically Relevant Testing
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A New, Advanced High-Throughput System for Automated Inhaler Testing
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