Breathing Simulators
From the generation of simple sinusoidal patterns as stated in the Ph. Eur. and USP for testing nebulisers and MDIs with a spacer/VHC, to complex user-generated profiles for improving in-vitro in-vivo correlations (IVIVCs), our range of Breathing Simulators can be used across a variety of testing applications and patient physiologies.
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BRS 300i Breathing Simulator
Similar in design and operation to the BRS 200i, the BRS 300i has a larger volume of 0 mL – 5 L. It also features a maximum flow rate of 240 L/min (free flow) and a maximum acceleration of 25L/s2 (free flow) making it the ideal unit for the testing of MDIs and DPIs for improved IVIVCs.
21 CFR Part 11 compliant
Stores and recalls methods
Powerful drive system for generating challenging profiles
Extensive data output options
Seamless integration with the Vertus® III range for automated shake, fire, and flow control in breath profile testing
Enhanced features including automatic data backups and report printing for greater efficiency and reliability
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BRS 300i Technical Specifications
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Volume:
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0 mL to 5 L
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Frequency:
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6 – 60 bpm
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I:E ratio:
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Variable
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Waveforms:
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Sinusoidal, Square, Triangular, User-defined (flow vs time)
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Profile:
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Inhalation and/or Exhalation
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Start:
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On inhalation or exhalation stroke / User-defined profiles (flow vs time)
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User interface:
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Touchscreen
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Uses:
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Limited testing of Nebulisers (Ph. Eur. 2.9.44 and USP <1601> and testing MDIs with Spacers/VHCs (USP <1602> | Improving IVIVCs for MDIs and DPIs: With DUSA for MDI/DPI (Dose Uniformity) With Impactor and Mixing Inlet (APSD)
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BRS 300i User Interface
- BRS 300i user log-in screen
- Pre-defined breathing pattern method selection
- Customisation and creation of breathing pattern methods
- Main run test screen (ready to test)
Related Accessories
Real-Time Breath Verification Chamber
Enables measurement and recording of the breathing profile generated through the inhaler during the actual test itself, using the Breath Profile Analyser BPA available in the Qualification Kit for BRSi Series (Cat. No. 9115) required. For use with the USP Induction Port only.
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Real-Time Breath Verification Chamber
Enables measurement and recording of the breathing profile generated through the inhaler during the actual test itself, using the Breath Profile Analyser BPA available in the Qualification Kit for BRSi Series (Cat. No. 9115) required. For use with the USP Induction Port only.
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