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DDU of Nebulisers

The delivered dose testing of a nebulisers is carried out to determine the total amount of drug a patient might be expected to receive during a treatment period, rather than through one inhalation. Given the mode of operation of nebulisers, well-defined tidal breathing profiles for specific patient types are specified for testing. The two tests specified in the Pharmacopoeias to characterise delivered dose, Active Substance Delivery Rate and Total Active Substance Delivered, are based on tidal flow conditions generated by a breathing simulator, as opposed to fixed flow rates.

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DDU of Dry Powder Inhalers (DPIs)

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Advanced Filter Holder

The new Advanced Filter Holder is designed specifically to improve efficiency and robustness in DDU testing of nebuliser products and MDIs with Spacers/Valved Holding Chambers. A single-piece, hinged design ensures a leak free process, simplifies filter replacement and enables rinsing in situ.

Manufactured from the same material as Copley DUSA tubes to ensure solvent compatibility during recovery and cleaning.
Durable, leak-free design
Compatible with the Sample Preparation Unit (SPU) for automation of the recovery process.

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We also offer a range of equipment for additional MDI testing application support:

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Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.

IVIVC Test Systems for DDU and APSD

Two factors have been identified as being critical…

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One of the main factors influencing the amount of inhaled drug available to the patient is the interface between the facemask and the patient. Investigating and defining the effect of a facemask to the product’s DDU and APSD is important for the product development.