APSD of Dry Powder Inhalers (DPIs)

The APSD measurement of Dry Powder Inhalers is typically performed under the same conditions as DDU testing, however a Preseparator is typically interposed between the induction port and stage 0 of cascade impactor to capture the large, non-inhalable carrier particles, to prevent impactor over-loading (when using an NGI or ACI). As for delivered dose DPI testing, test flow rate is set on the basis of a 4 kPa pressure drop across the device, to approximate the mean patient inhalation flow rate achieved during clinical use.

Dry Powder Inhalers (DPI)

NGI Preseparator

For the collection of large mass, non-inhalable powder blouses typically emitted from a DPI prior to entry into the impactor, to prevent impactor over-loading.

  • High capacity
  • High efficiency
  • Two-stage separation
  • Sharp and reproducible cut-point between 10-15 microns (depending on flow rate)
View Brochure

Induction Port P1 Measurement Adapter

Used together with the Critical Flow Controller, the Induction Port P1 Measurement Adapter can be placed between the inhaler and the induction port to measure the pressure drop (P1) over the inhaler under test in the absence of a DUSA for DPIs.

View Brochure

Automation Tools

Improve efficiency
Reduce variability
Eliminate handling error
Increase testing capacity

How Does a Cascade Impactor Work?

Play Video

Related Services

Related News & Resources

Copley introduces the new Flow Rate Sensor, a dedicated device for inhaler testing systems.

27th June 2023

Find out more

Introducing the Copley Impactor Genie™ IG 200i, a two-in-one solution for quicker, more efficient inhaled product testing

25th April 2023

Find out more

Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing

14th September 2022

Find out more

Copley launches a new semi-automation tool for inhaled product testing

28th April 2022

Find out more

Introducing Inhalytix®: a new solution for analysing and managing inhaler test data from Copley

18th March 2021

Find out more

Copley announces a major upgrade of the world’s ‘go to’ inhaler testing portfolio

1st March 2021

Find out more

New e-Training service from Copley for pharmaceutical testing

29th January 2021

Find out more

Advancing the science of OINDPs: Copley Scientific joins IPAC-RS

28th February 2018

Find out more

Confused about cascade impaction? Watch the new animations from Copley Scientific to improve your understanding of inhaled drug product testing.

22nd August 2016

Find out more

New maintenance tools from Copley Scientific help optimise inhaler testing

30th June 2009

Find out more

New, state-of-the-art vision system central to Copley Scientific’s cascade impactor validation service

24th July 2007

Find out more

Q&A: OINDPnews 2022

View download

DDD 2021 Respiratory eBook Profile

View download

PMPS Q&A (Samedan): April 2021

View download

Microbioz India: February 2021

View download

ONdrugDelivery Article: November 2020

View download

Inhalation Article: December 2019

View download

Inhalation Article: April 2019

View download

ONdrugDelivery Article: December 2018

View download

Drug Development & Delivery Article: April 2018

View download

PMPS Article (Samedan): February 2018

View download

White Paper: February 2018

View download