APSD of Nasal Products
Nasal drug products typically produce droplets larger than 10-20 microns, to ensure nasal deposition and minimise deposition within the lungs. However, a proportion of fine droplets in the <10 micron range may also be produced. Deposition of this respirable fraction beyond the nasal tract may be undesirable and must be quantified. Aerodynamic particle sizing with a cascade impactor is a US FDA requirement and is recommended in USP <601> to assess potential deposition beyond the nasal cavity.
Our nasal product testing solutions enable better, more informative testing in line with evolving market requirements.
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The angle of the impactor can be adjusted to replicate the angle that the nasal powder device may be used at to investigate device performance under representative conditions. The APSD measurement is unaffected by gravimetric forces.
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We also offer a range of equipment for additional nebuliser testing application support:
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Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
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Semi-Automation Tools
Improve efficiency
Reduce variability
Eliminate handling error
Increase testing capacity Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
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Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
Sample Preparation Unit SPU 200i
Copley supplies a broad range of labour-saving dev…
View Product RangeSemi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
How Does a Cascade Impactor Work?
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