APSD of Nasal Products

Nasal drug products typically produce droplets larger than 10-20 microns, to ensure nasal deposition and minimise deposition within the lungs. However, a proportion of fine droplets in the <10 micron range may also be produced. Deposition of this respirable fraction beyond the nasal tract may be undesirable and must be quantified. Aerodynamic particle sizing with a cascade impactor is a US FDA requirement and is recommended in USP <601> to assess potential deposition beyond the nasal cavity.

Our nasal product testing solutions enable better, more informative testing in line with evolving market requirements.

The angle of the impactor can be adjusted to replicate the angle that the nasal powder device may be used at to investigate device performance under representative conditions. The APSD measurement is unaffected by gravimetric forces.

Related Applications

We also offer a range of equipment for additional nebuliser testing application support:

Semi-Automation Tools

Improve efficiency
Reduce variability
Eliminate handling error
Increase testing capacity

How Does a Cascade Impactor Work?

Play Video

Related Services

Related News & Resources

Copley introduces the new Flow Rate Sensor, a dedicated device for inhaler testing systems.

27th June 2023

Find out more

Introducing the Copley Impactor Genie™ IG 200i, a two-in-one solution for quicker, more efficient inhaled product testing

25th April 2023

Find out more

Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing

14th September 2022

Find out more

Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

22nd June 2021

Find out more

Introducing Inhalytix®: a new solution for analysing and managing inhaler test data from Copley

18th March 2021

Find out more

Copley introduces a comprehensive range for nasal product testing

11th March 2021

Find out more

Nasal Product Testing Brochure 2023 (2 mb)

View download

White paper: October 2023

View download

PMPS Q&A (Samedan): April 2023

View download

Q&A: OINDPnews 2022

View download

ONdrugDelivery Article: November 2021

View download

DDD 2021 Respiratory eBook Profile

View download

Microbioz India: February 2021

View download