APSD of Nasal Products
Nasal drug products typically produce droplets larger than 10-20 microns, to ensure nasal deposition and minimise deposition within the lungs. However, a proportion of fine droplets in the <10 micron range may also be produced. Deposition of this respirable fraction beyond the nasal tract may be undesirable and must be quantified. Aerodynamic particle sizing with a cascade impactor is a US FDA requirement and is recommended in USP <601> to assess potential deposition beyond the nasal cavity.
Our nasal product testing solutions enable better, more informative testing in line with evolving market requirements.
Nosepiece Adapter
View ProductUSP Induction Port
View BrochureAndersen Cascade Impactor ACI
View BrochureInhaler Testing Workstation ITW
View ProductTPK 100i Critical Flow Controller
View ProductFlow Rate Sensor FRS
View ProductHCP6 High Capacity Vacuum Pump
View ProductTemperature and Relative Humidity Sensor
View BrochureDFM 2000 Flow Meter
View ProductFootswitch
View BrochureNGI Cup Rack
View BrochureNGI Carrying/Washing Rack
View BrochureDDU of Nasal Products
View SystemNosepiece Adapter
View ProductUSP Induction Port
View BrochureAndersen Cascade Impactor ACI
View BrochureInhaler Testing Workstation ITW
View ProductTPK 100i Critical Flow Controller
View ProductFlow Rate Sensor FRS
View ProductHCP6 High Capacity Vacuum Pump
View ProductTemperature and Relative Humidity Sensor
View BrochureDFM 2000 Flow Meter
View ProductFootswitch
View BrochureNGI Cup Rack
View BrochureNGI Carrying/Washing Rack
View BrochureDDU of Nasal Products
View SystemThe angle of the impactor can be adjusted to replicate the angle that the nasal powder device may be used at to investigate device performance under representative conditions. The APSD measurement is unaffected by gravimetric forces.
Related Applications
We also offer a range of equipment for additional nebuliser testing application support:
Related Applications
Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
View MoreSemi-Automation Tools
Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product RangeSemi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product RangeSemi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product RangeSample Preparation Unit SPU 200i
Copley supplies a broad range of labour-saving dev…
View Product RangeSemi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product RangeSemi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product RangeHow Does a Cascade Impactor Work?
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Copley Scientific joins the Industries Forum of the Taskforce for Lung Health
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Copley introduces a comprehensive range for nasal product testing
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Nasal Product Testing Brochure 2023 (4 mb)
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White paper: October 2023
Understanding the links between drug delivery route and in vitro test methods In this white paper, we review the drug product characteristics that define…
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PMPS Q&A (Samedan): April 2023
Nasal Drug Product Development Matthew Fenn, Head of Business Development, sat down with PMPS Magazine to discuss the topic of nasal drug testing and…
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Q&A: OINDPnews 2022
Reducing Inhaler Testing Variability Through Test Environment Control In this Q&A with OINDPnews, our CEO Mark Copley answers questions about the importance of the…
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ONdrugDelivery Article: November 2021
Improving In Vitro Test Methods for Nasal Drug Products In this article, we look at how in vitro testing is being refined for greater repeatability…
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DDD 2021 Respiratory eBook Profile
Semi-Automating Inhaler Testing – A Good Idea, but Where to Start? Cascade impaction is a vital technique in the development and manufacture of orally…
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Microbioz India: February 2021
A short Q&A with our CEO, Mark Copley, on inhaled product testing
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