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APSD of Nasal Products

Nasal sprays, nasal aerosols and nasal powders typically produce droplets in the range 20-200 microns, which is outside the effective range of cascade impactors. However, each may deliver a proportion of fine droplets in the <10 micron range. It is important to quantify this FPD since it can penetrate beyond the nasal tract and into the lower respiratory tract or lungs, which may be undesirable. Regulators recommend the use of a cascade impactor in conjunction with a high volume expansion chamber to quantify the amount of drug in the <10 micron range, to assess the potential risk of deposition in the lungs.

Nasal Sprays

Nasal Aerosols

Nasal Powders

Nasal Sprays

Nasal Aerosols

Nasal Powders

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)

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Please select an option:

Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI)

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The angle of the impactor can be adjusted to replicate the angle that the nasal powder device may be used at to investigate device performance under representative conditions. The APSD measurement is unaffected by gravimetric forces.

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Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.

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Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.

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How Does a Cascade Impactor Work?

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APSD of Nasal Products

Nosepiece Adapter

USP Induction Port

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TPK 100i Critical Flow Controller

DFM 2000 Flow Meter

HCP6 High Capacity Vacuum Pump

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Temperature and Relative Humidity Sensor

Footswitch

NGI Cup Rack

NGI Carrying/Washing Rack

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Nosepiece Adapter

USP Induction Port

Andersen Cascade Impactor ACI

Inhaler Testing Workstation ITW

TPK 100i Critical Flow Controller

DFM 2000 Flow Meter

HCP6 High Capacity Vacuum Pump

Inhalytix® – APSD Data Analysis Software

Temperature and Relative Humidity Sensor

Footswitch

NGI Cup Rack

NGI Carrying/Washing Rack

DDU of Nasal Products

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Impactor Coater™ IC 200i

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Gentle Rocker™ GR 200i

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Sample Preparation Unit SPU 200i

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NGI Assistant

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Impactor Cleaning System

How Does a Cascade Impactor Work?

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