Like nasal sprays, nasal aerosols also typically produce droplets in the range 20-200 microns, which is outside the effective range of cascade impactors. However, most sprays typically deliver a proportion (typically <5%) of fine droplets in the <10 micron range, which must be quantified.
Used together with a cascade impactor such as the Andersen Cascade Impactor (ACI) and a high volume expansion chamber, such as the Glass Expansion Chamber, the Vertus® II/Vertus® Plus automated shake, fire and flow control systems can be used to meet the need for highly consistent nasal spray actuation as recommended by USP <601>.
Shot weight measurement
The Vertus® Plus model includes an integrated analytical balance for automated nasal spray shot weight measurement.
Nasal Aerosols: Semi-Automated APSD Measurement
The Vertus® automated shake, fire and flow range is made up of integrated turn-key solutions for precise, controlled and reproducible nasal spray testing. Compatible with most nasal sprays, the Vertus II or Vertus Plus offers analysts complete control over:
- The speed, angle and duration of shaking, ahead of actuation
- Firing force and the speed of application and release of that force
- The time delay between the end of shaking and device actuation
How Does a Cascade Impactor Work?
Manual Nasal Spray Sampling
In addition to the Vertus® automated shake, fire and weigh systems, we offer a full suite of products to support manual testing, including flow meters, flow controllers and vacuum pumps.View manual the system
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