DDU of Nasal Products

Recent developments in nasal delivery systems has resulted in greater focus on different uses for drug delivery. With great potential for rapid drug absorption into the turbinates and lymphoid tissues located at the back of the nasal cavity, focus has shifted to absorption into the systemic circulation and central nervous system for a wider range of treatments.

Our nasal spray testing solutions enable better, more informative testing in line with evolving market requirements.

DUSA Interface Plate for Nasal Sprays

Simplifying the measurement of delivered dose uniformity testing for nasal sprays in accordance with the European Pharmacopoeia (Ph. Eur.) Chapter 0676 and United States Pharmacopoeia (USP) Chapter <601>, the nasal dose uniformity sampling apparatus (DUSA) interface plate enables simple, leak-free connection between a standard DUSA and the nasal drug product to ensure complete dose capture. Designed for use with the Vertus® III/III+ automated shake and fire system, routine test set-ups for nasal drug products are now easily automated using our complete integrated solution.

  • Apparatus as specified in USP Chapter <601> and Ph.Eur. 0676
  • Automated nasal spray shaking (Vertus® III/+)
  • Automated nasal spray actuation (Vertus® III/+)
  • Automated flow control (Vertus® III/+)
  • Automated shot weight measurement (Vertus® III+)

Shake. Fire. Weigh. Repeat.

The Vertus® III+ model has the additional feature of a 5-decimal place balance for automated nasal spray shot weight measurement. Automatically recording the mass of the inhaler at any point during a method, the Vertus Plus conveniently reports shot weight data along with all other test information.

 

Vertus® III Range – Automated Shake and Fire Systems for MDIs, Nasal Sprays and Nasal Aerosols

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Manual Nasal Spray Testing

As recommended in Ph. Eur. 0676 and USP <601>, we also offer the Inhaler Testing Workstation ITW with a DUSA holder that can be oriented in a vertical or near-vertical position for more representative manual nasal spray DDU testing. Product orientation for fire-to-waste can also match dose collection to help ensure data capture is more consistent and truly reflects performance with our innovative vertical Waste Shot Collector WSC2 attachment.

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Related Applications

We also offer a range of equipment for additional nasal spray testing application support:

Related Services

Related News & Resources

New, automated shake and fire platforms from Copley cut the burden of MDI and nasal drug product testing.

7th November 2023

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New IPAC-RS paper offers insight and guidance for testing aqueous nasal inhalation products

2nd November 2023

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Copley introduces the new Flow Rate Sensor, a dedicated device for inhaler testing systems.

27th June 2023

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The new DUSA Shaker™ DTS 100i from Copley: For faster, safer, more repeatable inhaler testing

8th February 2023

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Copley launches EnviroMate™, an efficient, benchtop environmental chamber for inhaler testing

14th September 2022

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New accessory completes Copley’s solution for automated nasal drug product testing

26th October 2021

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Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

22nd June 2021

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Copley introduces a comprehensive range for nasal product testing

11th March 2021

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Nasal Product Testing Brochure 2023

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Perfect Timing for the Automation of OINDP Testing

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Understanding the Links Between Drug Delivery Route and In Vitro Test Methods

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Nasal Drug Product Development

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Reducing Inhaler Testing Variability Through Test Environment Control

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Improving In Vitro Test Methods for Nasal Drug Products

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Refining Test Methods for a New Generation of Nasal Drug Products

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Semi-Automating Inhaler Testing – A Good Idea, but Where to Start?

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A short Q&A with our CEO, Mark Copley, On Inhaled Product Testing

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