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DDU of Nasal Products

Recent developments in nasal delivery systems have resulted in a greater focus on different uses for drug delivery. With great potential for rapid drug absorption into the turbinates and lymphoid tissues located at the back of the nasal cavity, focus has shifted to absorption into the systemic circulation and central nervous system for a wider range of treatments.

Our nasal spray testing solutions enable better, more informative testing in line with evolving market requirements.

Nasal Sprays (KNI)

Nasal Aerosols

Nasal Powders

Nasal Sprays (KNI)

Nasal Aerosols

Nasal Powders

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Kiel Nasal Inlet (KNI) Dose Uniformity Sampling Apparatus (DUSA) Nasal Spray Dose and Waste Collectors (NSDC & NSWC)

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Kiel Nasal Inlet (KNI) Dose Uniformity Sampling Apparatus (DUSA) Nasal Spray Dose and Waste Collectors (NSDC & NSWC)

DUSA Interface Plate for Nasal Sprays

Simplifying the measurement of delivered dose uniformity testing for nasal sprays in accordance with the European Pharmacopoeia (Ph. Eur.) Chapter 0676 and United States Pharmacopoeia (USP) Chapter <601>, the nasal dose uniformity sampling apparatus (DUSA) interface plate enables simple, leak-free connection between a standard DUSA and the nasal drug product to ensure complete dose capture. Designed for use with the Vertus® III/III+ automated shake and fire system, routine test set-ups for nasal drug products are now easily automated using our complete integrated solution.

Apparatus as specified in USP Chapter <601> and Ph.Eur. 0676
Automated nasal spray shaking (Vertus® III/+)
Automated nasal spray actuation (Vertus® III/+)
Automated flow control (Vertus® III/+)
Automated shot weight measurement (Vertus® III+)

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Kiel Nasal Inlet (KNI) Dose Uniformity Sampling Apparatus (DUSA) Nasal Spray Dose and Waste Collectors (NSDC & NSWC)

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Shake. Fire. Weigh. Repeat.

The Vertus® III+ model has the additional feature of a 5-decimal place balance for automated nasal spray shot weight measurement. Automatically recording the mass of the inhaler at any point during a method, the Vertus Plus conveniently reports shot weight data along with all other test information.

Learn more: Vertus® III+

Vertus® III Range – Automated Shake and Fire Systems for MDIs, Nasal Sprays and Nasal Aerosols

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Manual Nasal Spray Testing

We also offer a range of testing apparatus for manual nasal spray testing.

As recommended in Ph. Eur. 0676 and USP <601>, we offer the Inhaler Testing Workstation ITW with a DUSA holder that can be oriented in a vertical or near-vertical position for more representative manual nasal spray DDU testing. Product orientation for fire-to-waste can also match dose collection to help ensure data capture is more consistent and truly reflects performance with our innovative vertical Waste Shot Collector WSC2 attachment.

New for 2025 – The Angled Nasal Spray Holder (cat. no. 8143) for the Inhaler Testing Workstation ITW enables precise orientation of nasal spray devices at selectable firing angles (±45°), supporting consistent and repeatable dose uniformity testing. For more information, please contact sales@copleyscientific.co.uk.

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Related Applications

We also offer a range of equipment for additional nasal spray testing application support:

Related Applications

Cold Freon®” effect is the inadvertent reaction to the chilling sensation that hits the back of the throat following actuation of usually MDIs or Nasal devices.