APSD of Nasal Products
Nasal drug products typically produce droplets larger than 10-20 microns, to ensure nasal deposition and minimise deposition within the lungs. However, a proportion of fine droplets in the <10 micron range may also be produced. Deposition of this respirable fraction beyond the nasal tract may be undesirable and must be quantified. Aerodynamic particle sizing with a cascade impactor is a US FDA requirement and is recommended in USP <601> to assess potential deposition beyond the nasal cavity.
Our nasal product testing solutions enable better, more informative testing in line with evolving market requirements.
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Nasal Spray Dose Collector (NSDC)
Specially designed for nasal spray DDU testing, the NSDC has an optimised internal geometry to eliminate splashback, drips and leakage following actuation to ensure complete spray dose capture every time.
Designed for use with the Vertus® III/+ automated shake and fire systems, the NSDC enables reproducible and time efficient nasal spray testing. It can also be used as a standalone device for the manual dose collection of nasal sprays.
Nasal Spray Waste Collector (NSWC)
Streamlining nasal spray wasting, the NSWC is designed to collect high volumes of waste aerosol doses with no splashback onto the nozzle for safe and convenient disposal of waste drug product.
Designed for use with the Vertus® III/+ automated shake and fire systems, the NSWC improves the speed and efficiency of nasal spray wasting.
Nasal Aerosols: Semi-Automated APSD Measurement
The Vertus® III automated shake, fire and flow range is made up of integrated turn-key solutions for precise, controlled and reproducible nasal aerosol testing. Compatible with most nasal aerosols, the Vertus III or Vertus III+ offers analysts complete control over:
- The speed, angle and duration of shaking, ahead of actuation
- Firing force and the speed of application and release of that force
- The time delay between the end of shaking and device actuation
How Does a Cascade Impactor Work?
Manual Nasal Aerosol Sampling
In addition to the Vertus® automated shake, fire and flow systems, we offer a full suite of products to support manual testing, including flow meters, flow controllers and vacuum pumps.
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We also offer a range of equipment for additional nasal aerosol testing application support:
Related Applications
Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.
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Semi-Automation Tools
Improve efficiency
Reduce variability
Eliminate handling error
Increase testing capacity Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
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Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
Semi-Automation Tools
Copley supplies a broad range of labour-saving devices and semi-automated systems for Aerodynamic Particle Size Distribution applications.
View Product Range
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Servicing
A comprehensive range of both in-house and on-site product servicing options are available
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Support
Our team of experienced technicians and engineers are on hand to help and advise
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