DDU of Nasal Products

Nasal Spray Dose Collector (NSDC)

Specially designed for nasal spray DDU testing, the NSDC has an optimised internal geometry to eliminate splashback, drips and leakage following actuation to ensure complete spray dose capture every time.

Designed for use with the Vertus® III/+ automated shake and fire systems, the NSDC enables reproducible and time efficient nasal spray testing. It can also be used as a standalone device for the manual dose collection of nasal sprays.

Nasal Spray Waste Collector (NSWC)

Streamlining nasal spray wasting, the NSWC is designed to collect high volumes of waste aerosol doses with no splashback onto the nozzle for safe and convenient disposal of waste drug product.

Designed for use with the Vertus® III/+ automated shake and fire systems, the NSWC improves the speed and efficiency of nasal spray wasting.

Developed by Kiel University and commercialised in partnership with Copley Scientific, the Kiel Nasal Inlet (KNI) is a robust, precision-engineered dose collection apparatus designed to support reliable delivered dose uniformity (DDU) and aerodynamic particle size distribution (APSD) testing of nasal drug products actuated vertically or near-vertically.

The KNI enables complete dose capture while minimising splashback, drips and leakage – ensuring accurate and reproducible results. Its vented design allows it to be used for DDU testing, with or without an applied airflow, and in conjunction with an induction port for APSD testing. The KNI supports the evaluation of the mass fraction of particles and droplets <10μm, in line with EMA and FDA guidance.

Compatible with both the Next Generation Impactor (NGI) and the Andersen Cascade Impactor (ACI), and made from the same solvent-resistant materials as Copley DUSA tubes, the KNI is ideally suited for use in commercial R&D and QC environments.

• Enables DDU and APSD testing of nasal sprays actuated vertically or near-vertically
• Minimises loss from splashback, drips, and leakage to ensure accurate dose collection
• Vented design ensures a more clinically realistic application when used with an applied air flow.
• Supports regulatory guidance (EMA and FDA) for testing particles/droplets <10μm
• Compatible with NGI and ACI
• Solvent-resistant construction for proven recovery and easy cleaning
• Precision-engineered with serialised marking for traceability
• Developed in collaboration with the Department of Pharmaceutics and Biopharmaceutics at Kiel University, Germany