Recent developments in nasal delivery systems has resulted in greater focus on different uses for drug delivery. Previously the typical nasal preparations were used for the local administration of anti-histamines, decongestants and steroids. Now however the spotlight has moved, focusing on absorption into the systemic circulation and central nervous system.
The former has great potential for rapid drug absorption into the turbinates and lymphoid tissues located at the back of the nasal cavity. This is already in use in a number of areas including migraines and pain relief.
Entry into the central nervous system through the olfactory region at the top of the nasal cavity provides the potential for “Nose to Brain” treatment. This is ideal from treating diseases such as Alzheimer's Disease.
There are three conventional technologies for Nasal Delivery System, Metered Spray Pumps (Aqueous based), Powder based Nasal Devices and Propellant based Nasal Aerosols (MDIs)