APSD of Nasal Products

Nasal sprays, nasal aerosols and nasal powders typically produce droplets in the range 20-200 microns, which is outside the effective range of cascade impactors. However, each may deliver a proportion of fine droplets in the <10 micron range. It is important to quantify this FPD since it can penetrate beyond the nasal tract and into the lower respiratory tract or lungs, which may be undesirable. Regulators recommend the use of a cascade impactor in conjunction with a high volume expansion chamber to quantify the amount of drug in the <10 micron range, to assess the potential risk of deposition in the lungs.

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Nasal Sprays: Semi-Automated APSD Measurement

The Vertus automated shake, fire and shot waste range is made up of integrated turn-key solutions for precise, controlled and reproducible nasal spray testing. Compatible with most nasal sprays, the Vertus II or Vertus Plus offers analysts complete control over:

The speed, angle and duration of shaking, ahead of actuation
Firing force and the speed of application and release of that force
The time delay between the end of shaking and device actuation

View the Vertus Range

Related Applications

We also offer a range of equipment for additional nasal spray testing application support:

IVIVC Test Systems for DDU and APSD

Semi-Automation Tools

Improve efficiency

Reduce variability

Eliminate handling errors

Increase testing capacity

Vertus® II

Maintaining a consistent and repeatable inhaler testing technique...

View Product Range

Vertus® Plus

Building on the original Vertus II shake and...

View Product Range

Gentle Rocker 100i

Designed to help ensure sample recovery is carried...

View Product Range

NGI Assistant

Designed to automate the HPLC sample preparation process,...

View Product Range

Impactor Cleaning System

Cascade impactors are precision instruments and should be...

View Product Range

Related Services

Training

We offer a range of training courses, presentations and seminars covering a wide range of topics....

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Servicing

A comprehensive range of both in-house and on-site product servicing options are available...

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Support

Our team of experienced technicians and engineers are on hand to help and advise ...

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APSD of Nasal Products

Nosepiece Adapter

Glass Expansion Chamber

Next Generation Impactor NGI

DFM 2000 Flow Meter

LCP6 Low Capacity Vacuum Pump

Inhalytix® - APSD Data Analysis Software

NGI Cup Rack

NGI Carrying/Wash Rack

DDU of Nasal Products

Nosepiece Adapter

Glass Expansion Chamber

Next Generation Impactor NGI

DFM 2000 Flow Meter

LCP6 Low Capacity Vacuum Pump

Inhalytix® - APSD Data Analysis Software

NGI Cup Rack

NGI Carrying/Wash Rack

DDU of Nasal Products

Nasal Sprays: Semi-Automated APSD Measurement

Related Applications

IVIVC Test Systems for DDU and APSD

Semi-Automation Tools

Vertus® II

Vertus® Plus

Gentle Rocker 100i

NGI Assistant

Impactor Cleaning System

How Does a Cascade Impactor Work?

Related Services

Training

Servicing

Support

Related News & Resources

RDD 2022 Poster: Chen et al.

ONdrugDelivery Article: November 2021

New accessory completes Copley’s solution for automated nasal drug product testing

Manufacturing Chemist Feature: July 2021

DDD 2021 Respiratory eBook Profile

Copley Scientific joins the Industries Forum of the Taskforce for Lung Health

Introducing Inhalytix™: a new solution for analysing and managing inhaler test data from Copley

Copley introduces a comprehensive range for nasal product testing

Microbioz India: February 2021