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APSD of Dry Powder Inhalers (DPIs)

The APSD measurement of DPIs is typically performed under the same conditions as DDU testing, however a Preseparator is typically interposed between the induction port and stage 0 of cascade impactor to capture the large, non-inhalable carrier particles, to prevent impactor over-loading (when using an NGI or ACI). As for delivered dose testing of DPIs, test flow rate is set on the basis of a 4 kPa pressure drop across the device, to approximate the mean patient inhalation flow rate achieved during clinical use.

DPIs

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI) Multi Stage Liquid Impinger (MSLI) Glass Twin Impinger (GTI)

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI) Multi Stage Liquid Impinger (MSLI) Glass Twin Impinger (GTI)

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI) Multi Stage Liquid Impinger (MSLI) Glass Twin Impinger (GTI)

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Next Generation Impactor (NGI) Andersen Cascade Impactor (ACI) Multi Stage Liquid Impinger (MSLI) Glass Twin Impinger (GTI)

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Related Applications

We also offer a range of equipment for additional DPI testing application support:

Related Applications

Two factors have been identified as being critical to improving the clinical relevance of DDU testing and APSD measurement: realistic breathing profiles and realistic throat and nasal models.