The Aerodynamic Particle Size Distribution of an MDI or BAI will determine where the particles in the aerosol cloud are likely to deposit following inhalation. If the particles are too large they will catch at the back of the throat. Too small, and they will be exhaled rather than deposited.
The instrument of choice for measuring the APSD of MDI or BAI products to meet both regulatory and pharmacopoeial requirements alike is the cascade impactor.
There are five different cascade impactors/impingers suitable for the assessment of APSD, however, only the Andersen Cascade Impactor (ACI), the Next Generation Impactor (NGI) and the Multi-Stage Liquid Impinger (MSLI) appear in both the US and European Pharmacopoeias.
22nd August 2016; Nottingham, UK: Copley Scientific, the world’s leading manufacturer and suppl...Find Out More
24 July 2007; Nottingham, UK: The accuracy of cascade impactors used in the pharmaceutical indust...Find Out More
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